肝硬化护理和肝移植中的健康差异

IF 5.7 1区 化学 Q2 CHEMISTRY, PHYSICAL Journal of Chemical Theory and Computation Pub Date : 2024-10-31 DOI:10.1038/s41575-024-01003-1
David Goldberg, Julius Wilder, Norah Terrault
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引用次数: 0

摘要

肝硬化的发病率和死亡率都很高,而且还在不断上升。肝硬化和肝移植的健康差异反映了从筛查和诊断到预防和治疗肝脏相关并发症的整个慢性肝病治疗过程中的不平等。在健康状况和医疗服务方面存在差异的主要人群包括少数种族和族裔群体、性和性别少数群体、社会经济地位较低的人群以及服务不足的农村社区。这些差异导致慢性肝病和肝硬化并发症(如肝细胞癌)的诊断延迟,慢性肝病及其并发症的治疗存在差异,最终导致终末期肝病患者接受移植的机会不平等。指出这些差异只是实施解决方案的第一步,这些解决方案可以改善每个人的健康公平和临床结果。我们需要在慢性肝病的治疗过程中采取多层次的干预措施,以减少这些差距,并提供公平的治疗机会。
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Health disparities in cirrhosis care and liver transplantation

Morbidity and mortality from cirrhosis are substantial and increasing. Health disparities in cirrhosis and liver transplantation are reflective of inequities along the entire spectrum of chronic liver disease care, from screening and diagnosis to prevention and treatment of liver-related complications. The key populations experiencing disparities in health status and healthcare delivery include racial and ethnic minority groups, sexual and gender minorities, people of lower socioeconomic status and underserved rural communities. These disparities lead to delayed diagnosis of chronic liver disease and complications of cirrhosis (for example, hepatocellular carcinoma), to differences in treatment of chronic liver disease and its complications, and ultimately to unequal access to transplantation for those with end-stage liver disease. Calling out these disparities is only the first step towards implementing solutions that can improve health equity and clinical outcomes for everyone. Multi-level interventions along the care continuum for chronic liver disease are needed to mitigate these disparities and provide equitable access to care.

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来源期刊
Journal of Chemical Theory and Computation
Journal of Chemical Theory and Computation 化学-物理:原子、分子和化学物理
CiteScore
9.90
自引率
16.40%
发文量
568
审稿时长
1 months
期刊介绍: The Journal of Chemical Theory and Computation invites new and original contributions with the understanding that, if accepted, they will not be published elsewhere. Papers reporting new theories, methodology, and/or important applications in quantum electronic structure, molecular dynamics, and statistical mechanics are appropriate for submission to this Journal. Specific topics include advances in or applications of ab initio quantum mechanics, density functional theory, design and properties of new materials, surface science, Monte Carlo simulations, solvation models, QM/MM calculations, biomolecular structure prediction, and molecular dynamics in the broadest sense including gas-phase dynamics, ab initio dynamics, biomolecular dynamics, and protein folding. The Journal does not consider papers that are straightforward applications of known methods including DFT and molecular dynamics. The Journal favors submissions that include advances in theory or methodology with applications to compelling problems.
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