接触免疫检查点抑制剂后的生育结果

IF 48.8 1区医学 Q1 CELL BIOLOGY Cancer Cell Pub Date : 2024-10-31 DOI:10.1016/j.ccell.2024.10.005

Emily C. Harrold, Martinique Ogle, Erin O’Brien, Callahan Wilde, Jenna Sinopoli, Jill Weiss, Lauren Martino, Anne Casson, Hey-Joo Kang, Michael Postow, Andrea Cercek

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引用次数: 0

摘要

Harrold 等人评估了检查点抑制剂阻断（ICB）对生育的影响，证明与子宫内暴露不同，暴露后受孕似乎会导致不复杂的妊娠和健康的后代。他们展示了在接触 ICB 之前、期间和之后，以及在胚胎成功植入之前，对女性荷尔蒙波动的实时监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fertility outcomes post immune checkpoint inhibitor exposure

Harrold et al. evaluate the fertility impact of checkpoint inhibitor blockade (ICB), demonstrating that unlike in utero exposure, post-exposure conception appears to result in uncomplicated pregnancies and healthy progeny. They demonstrate contemporaneous monitoring of temporal female hormonal fluctuations before, on, and post ICB exposure and prior to successful embryo implantation.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.