精准肿瘤学和癌症转化研究中的高度复用组织成像。

IF 29.7 1区 医学 Q1 ONCOLOGY Cancer discovery Pub Date : 2024-11-01 DOI:10.1158/2159-8290.CD-23-1165
Alina Bollhagen, Bernd Bodenmiller
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引用次数: 0

摘要

精准肿瘤学根据患者的分子和健康数据制定治疗策略。尽管目前的诊断方法具有重要的临床价值,但苏木精和伊红形态学、免疫组化和基因组测序只能提供不完整的特征描述。相比之下,高度复用的组织成像技术能以单细胞分辨率对数十种标记物进行空间分析,从而对复杂的肿瘤生态系统进行分析;因此,它有可能促进我们对癌症生物学的了解,并支持药物开发、生物标记物发现和患者分层。我们介绍了现有的高度复用成像模式,讨论了它们在临床应用中的优缺点,以及将这些模式应用于临床实践的潜在途径。意义重大:本综述就如何将患者样本的高分辨率多重组织成像整合到临床工作流程中提供了指导。它系统地比较了现有技术和新兴技术,并概述了在精准肿瘤学领域的潜在应用,从而将不断发展的癌症研究与高度多重组织成像在常规临床实践中的实际应用可能性联系起来。
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Highly Multiplexed Tissue Imaging in Precision Oncology and Translational Cancer Research.

Precision oncology tailors treatment strategies to a patient's molecular and health data. Despite the essential clinical value of current diagnostic methods, hematoxylin and eosin morphology, immunohistochemistry, and gene panel sequencing offer an incomplete characterization. In contrast, highly multiplexed tissue imaging allows spatial analysis of dozens of markers at single-cell resolution enabling analysis of complex tumor ecosystems; thereby it has the potential to advance our understanding of cancer biology and supports drug development, biomarker discovery, and patient stratification. We describe available highly multiplexed imaging modalities, discuss their advantages and disadvantages for clinical use, and potential paths to implement these into clinical practice. Significance: This review provides guidance on how high-resolution, multiplexed tissue imaging of patient samples can be integrated into clinical workflows. It systematically compares existing and emerging technologies and outlines potential applications in the field of precision oncology, thereby bridging the ever-evolving landscape of cancer research with practical implementation possibilities of highly multiplexed tissue imaging into routine clinical practice.

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来源期刊
Cancer discovery
Cancer discovery ONCOLOGY-
CiteScore
22.90
自引率
1.40%
发文量
838
审稿时长
6-12 weeks
期刊介绍: Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.
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