双重 GIP 和 GLP-1 受体激动剂--替扎帕肽在减肥管理中的作用;系统性综述。

IF 1.1 Q4 PHARMACOLOGY & PHARMACY Current drug safety Pub Date : 2024-10-31 DOI:10.2174/0115748863330434241015125302
Imran Rashid Rangraze, Shehla Khan, Adil Farooq Wali, Godfred Menezes, Manjunatha Goud, Muhammad Jabran
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引用次数: 0

摘要

目的:本综述探讨了替哌肽作为一种二元GIP和GLP- 1受体激动剂治疗肥胖症和代谢性疾病的可能性:背景:对替泽帕肽的定义是,鉴于其疗效依赖性,它是一种隐性的肥胖症干预措施。除了对体重减轻有益外,替扎帕肽还能改善血脂和胰岛素敏感性,并与二元受体激活相协调:方法:通过对七项第三阶段试验的数据进行分析,结果表明替瑞沙肽能显著减轻体重,而且对不同的人群和不同的时间长度都有临床意义:结果:该药物的效果得到了其良好安全性的支持,其常见不良反应发生率较低。它在治疗 2 型糖尿病方面的疗效得到了相对评价的支持,这凸显了它作为一种治疗手段取得突破的必然性。治疗的个体化是关键,基于出生体重指数的分组分析所提出的量身定制的对策就是证明。结论:结论:通过长期随访研究证实,替扎帕肽可作为治疗习惯性肥胖的长期策略,并可持续减轻体重。尽管取得了这些令人鼓舞的结果,但仍需要进一步的研究和临床经验,以全面了解替扎帕肽在不同患者群体中的安全性、最佳整合性和长期有效性。
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Role of Dual GIP and GLP-1 Receptor Agonist, Tirzepatide in the Management of Weight Loss; A Systematic Review.

Aim: The eventuality of tirzepatide, a binary GIP and GLP- 1 receptor agonist, as a treatment for rotundity and metabolic diseases is addressed in this comprehensive review.

Background: A definition of tirzepatide is that it is an implicit intervention for rotundity, given its effectualness per the cure-dependent effect. Beyond the beneficial effects on body weight loss, tirzepatide also brings about an improvement in lipid biographies and insulin perceptivity, in harmony with binary receptor activation.

Methodology: Assaying data from seven phases 3 trials, it's constantly shown that tirizepatide reduces body weight in a significant and clinically meaningful way for a variety of party biographies and lengths of time.

Results: The drug's effect was supported by its favorable safety profile, which shows low prevalence rates of common adverse goods. Its efficacy in the management of type 2 diabetes is supported by relative evaluations, underscoring the inevitability of its breakthrough as a therapeutic volition. Treatment individualization is key, as evidenced by the tailor-made response proposed by group analysis based on birth BMI. The efficacy, safety, and demand for personalized treatment plans of tirzepatide are each supported in recommendations for clinical practice.

Conclusion: Tirzepatide's eventuality as a long-term strategy for habitual rotundity is corroborated by long-term follow-up studies that show sustained weight loss. Indeed with these encouraging results, further study and clinical experience are demanded to completely comprehend the safety, optimal integration, and long-term effectiveness of tirzepatide in a multiplicity of patient populations.

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来源期刊
Current drug safety
Current drug safety PHARMACOLOGY & PHARMACY-
CiteScore
2.10
自引率
0.00%
发文量
112
期刊介绍: Current Drug Safety publishes frontier articles on all the latest advances on drug safety. The journal aims to publish the highest quality research articles, reviews and case reports in the field. Topics covered include: adverse effects of individual drugs and drug classes, management of adverse effects, pharmacovigilance and pharmacoepidemiology of new and existing drugs, post-marketing surveillance. The journal is essential reading for all researchers and clinicians involved in drug safety.
期刊最新文献
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