用小分子靶向 Wnt 通路作为治疗心血管疾病的新方法

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Cardiology Reviews Pub Date : 2024-10-30 DOI:10.2174/011573403X333038241023153349
Seyed Mehdi Mousavi, Fatemeh Jalali-Zefrei, Mohammad Shourmij, Shiva Tabaghi, Amirhesam Davari, Saeed Bahador Khalili, Soghra Farzipour, Arsalan Salari
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引用次数: 0

摘要

与心血管疾病相关的发病率和死亡率不断上升,给临床治疗带来了巨大困难,并对患者的健康产生了重大影响。Wnt 信号通路具有高度保守性,因其在胚胎发育、组织再生和成人组织稳态中的调控作用而广为人知。Wnt 信号通路分为两种不同的通路:规范 Wnt/β-catenin 信号通路和非规范通路,包括平面细胞极性和 Wnt/Ca2+ 通路。越来越多的实验证据表明,规范和非规范 Wnt 信号通路都参与了心血管疾病的发生,包括心肌肥厚、心律失常、糖尿病心肌病、心律失常性心肌病和心肌梗死。因此,为了提高患者的生活质量,诊断和治疗心脏疾病可能需要深入了解 Wnt 通路在这些疾病中所发挥的分子功能。许多小分子抑制剂专门针对 Wnt 信号通路中的各种成分,如 Frizzled、Disheveled、Porcupine 和 Tankyrase。本研究旨在概述有关 Wnt 信号在人类心脏疾病中的功能以及可能的 Wnt 抑制剂的最新发现,从而为治疗心脏疾病提供新的方法。
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Targeting Wnt Pathways with Small Molecules as New Approach in Cardiovascular Disease.

The increasing incidences of morbidity and mortality associated with cardiovascular diseases represent significant difficulties for clinical treatment and have a major impact on patient health. Wnt signaling pathways are highly conserved and are well known for their regulatory roles in embryonic development, tissue regeneration, and adult tissue homeostasis. Wnt signaling is classified into two distinct pathways: canonical Wnt/β-catenin signaling and noncanonical pathways, including planar cell polarity and Wnt/Ca2+ pathways. A growing body of experimental evidence suggests the involvement of both canonical and non-canonical Wnt signaling pathways in the development of cardiovascular diseases, including myocardial hypertrophy, arrhythmias, diabetic cardiomyopathy, arrhythmogenic cardiomyopathy, and myocardial infarction. Thus, to enhance patient quality of life, diagnosing and treating cardiac illnesses may require a thorough understanding of the molecular functions played by the Wnt pathway in these disorders. Many small-molecule inhibitors specifically target various components within the Wnt signaling pathways, such as Frizzled, Disheveled, Porcupine, and Tankyrase. This study aims to present an overview of the latest findings regarding the functions of Wnt signaling in human cardiac disorders and possible inhibitors of Wnt, which could lead to novel approaches for treating cardiac ailments.

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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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