前列腺癌男性患者注射水凝胶垫片(Space OAR)后三维适形放射治疗的直肠毒性。

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL SAGE Open Medicine Pub Date : 2024-09-29 eCollection Date: 2024-01-01 DOI:10.1177/20503121241287086
Gen Kawaguchi, Kyohei Ishida, Hiroki Nishiyama, Yohei Ikeda, Noboru Hara, Tsutomu Nishiyama
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引用次数: 0

摘要

目的:评估前列腺癌局部放疗前注射水凝胶垫片(增加前列腺与直肠之间的距离)是否能减少直肠和膀胱毒性:经机构审查委员会批准(05-004),我们对随访一年以上的前列腺癌患者局部放疗后的直肠和膀胱毒性进行了回顾性研究:我们共纳入了 156 名接受过局部放射治疗的患者。他们的年龄从 63 岁到 86 岁不等,平均年龄为 75 岁。大多数患者只接受了前列腺和精囊的治疗。所有前列腺部位的照射情况如下:10 名患者的整个骨盆和前列腺,6 名患者的整个骨盆和前列腺及转移部位,8 名患者的前列腺和转移部位。对前列腺进行了放射治疗(70-74 Gy)。整个骨盆和主动脉旁淋巴结的照射剂量为 45-46.8 Gy,骨转移部位的照射剂量为 54-60 Gy。在一个病例中,对骶骨骨转移部位进行了立体定向体放射治疗(36 Gy)。39 名患者注射了水凝胶垫片。据报告,21 名未注射水凝胶垫片的患者(17.9%)和 3 名注射了水凝胶垫片的患者(7.7%)出现了直肠毒性。5名未注射水凝胶垫片的患者出现了膀胱毒性,只有一名患者注射了水凝胶垫片:结论:前列腺癌局部放疗前注射水凝胶垫片可减少直肠放射线照射,降低直肠并发症的风险,可能是未来提高照射剂量的一种有前途的方法。
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Rectal toxicity of 3-dimensional conformal radiation therapy following hydrogel spacer (Space OAR) injection for men with prostate cancer.

Purpose: To evaluate whether hydrogel spacer injection, which increases the distance between the prostate and rectum, prior to local radiation therapy for prostate cancer reduces rectal and bladder toxicity.

Patients and methods: With institutional review board approval (05-004), we retrospectively reviewed rectal and bladder toxicity after local radiation therapy in patients with prostate cancer who were followed up for more than 1 year.

Results: We included 156 patients who had received local radiation therapy. Their ages ranged from 63 to 86 years, with an average of 75 years. Most patients were treated only on the prostate and seminal vesicles. All prostate sites were irradiated as follows: whole pelvis with prostate in 10 patients, whole pelvis with prostate and metastatic sites in six, and prostate and metastatic sites in eight. Radiation therapy (70-74 Gy) was performed for the prostate. Irradiation of 45-46.8 Gy was applied to whole pelvic and para-aortic lymph nodes, with 54-60 Gy applied to bone metastatic sites. In one case, stereotactic body radiation therapy (36 Gy) was performed for a sacral bone metastatic site. The hydrogel spacer was injected in 39 patients. Rectal toxicity was reported in 21 patients without (17.9%) and 3 patients with (7.7%) the hydrogel spacer. Bladder toxicity was reported in five patients without and only one patient with the hydrogel spacer.

Conclusion: Hydrogel spacer injection prior to local radiation therapy for prostate cancer reduces rectal radiation exposure, lowers the risk of rectal complications, and may be a promising method for boosting the irradiation dose in the future.

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来源期刊
SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
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