Tae-Su Han, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho
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引用次数: 0
摘要
表观遗传修饰因子（miRNA、组蛋白甲基转移酶（HMT）/脱甲基酶和 DNA 甲基转移酶/脱甲基酶）与癌症的增殖、转移、血管生成和耐药性有关。在这些修饰因子中，HMTs 经常在各种癌症中过表达，最近的研究越来越多地发现这些蛋白是潜在的治疗靶点。在这篇综述中，我们将讨论 SET 和含 MYND 结构域蛋白（SMYD）家族的成员，它们是癌症相关基因组蛋白甲基化和非组蛋白甲基化广泛研究的主题。SMYD 家族的各种成员通过调节癌症特异性组蛋白甲基化和非组蛋白甲基化，在癌症增殖、转移和耐药性方面发挥着重要作用。因此，开发针对 SMYD 家族成员的特异性抑制剂可能会促进癌症治疗方法的开发，而与各种抗癌治疗药物的联合治疗可能会提高疗效。
SMYD family in cancer: epigenetic regulation and molecular mechanisms of cancer proliferation, metastasis, and drug resistance.
Epigenetic modifiers (miRNAs, histone methyltransferases (HMTs)/demethylases, and DNA methyltransferases/demethylases) are associated with cancer proliferation, metastasis, angiogenesis, and drug resistance. Among these modifiers, HMTs are frequently overexpressed in various cancers, and recent studies have increasingly identified these proteins as potential therapeutic targets. In this review, we discuss members of the SET and MYND domain-containing protein (SMYD) family that are topics of extensive research on the histone methylation and nonhistone methylation of cancer-related genes. Various members of the SMYD family play significant roles in cancer proliferation, metastasis, and drug resistance by regulating cancer-specific histone methylation and nonhistone methylation. Thus, the development of specific inhibitors that target SMYD family members may lead to the development of cancer treatments, and combination therapy with various anticancer therapeutic agents may increase treatment efficacy.
期刊介绍：
Experimental & Molecular Medicine (EMM) stands as Korea's pioneering biochemistry journal, established in 1964 and rejuvenated in 1996 as an Open Access, fully peer-reviewed international journal. Dedicated to advancing translational research and showcasing recent breakthroughs in the biomedical realm, EMM invites submissions encompassing genetic, molecular, and cellular studies of human physiology and diseases. Emphasizing the correlation between experimental and translational research and enhanced clinical benefits, the journal actively encourages contributions employing specific molecular tools. Welcoming studies that bridge basic discoveries with clinical relevance, alongside articles demonstrating clear in vivo significance and novelty, Experimental & Molecular Medicine proudly serves as an open-access, online-only repository of cutting-edge medical research.
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