{"title":"过敏原蛋白诱导的 I 型超敏反应模型:综述。","authors":"Yanhua Feng, Liangyu Xu, Jinming Zhang, Jinlian Bin, Xialing Pang, Sheng He, Lei Fang","doi":"10.3389/falgy.2024.1481011","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Type I hypersensitivity affects approximately one-third of the global population. As the pathophysiology underlying the development of type I hypersensitivity (asthma, food allergy, and anaphylactic shock, etc.) is complex and heterogeneous, animal model studies continue to be the key to identifying novel molecular pathways and providing therapeutic strategies.</p><p><strong>Objective: </strong>Selection of the animal model should be done with careful consideration of the protocol variables, animal species, and strains to accurately reflect the clinical symptoms typical of humans.</p><p><strong>Methods: </strong>The following databases were searched: PubMed and Web of Science.</p><p><strong>Results and conclusion: </strong>Foreign allergens include allergenic proteins and chemical haptens. This review summarizes the various methods used for designing animal models of common allergenic protein-induced type I hypersensitivity, namely, passive anaphylaxis model, active systemic anaphylaxis/anaphylaxis shock model, food allergy model, asthma model, and IgE-mediated cell models. Additionally, we summarize shrimp tropomyosin-induced type I hypersensitivity models from our previous studies and discuss their advantages and limitations compared with that of ovalbumin-induced models.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"5 ","pages":"1481011"},"PeriodicalIF":3.3000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525013/pdf/","citationCount":"0","resultStr":"{\"title\":\"Allergenic protein-induced type I hypersensitivity models: a review.\",\"authors\":\"Yanhua Feng, Liangyu Xu, Jinming Zhang, Jinlian Bin, Xialing Pang, Sheng He, Lei Fang\",\"doi\":\"10.3389/falgy.2024.1481011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>Type I hypersensitivity affects approximately one-third of the global population. As the pathophysiology underlying the development of type I hypersensitivity (asthma, food allergy, and anaphylactic shock, etc.) is complex and heterogeneous, animal model studies continue to be the key to identifying novel molecular pathways and providing therapeutic strategies.</p><p><strong>Objective: </strong>Selection of the animal model should be done with careful consideration of the protocol variables, animal species, and strains to accurately reflect the clinical symptoms typical of humans.</p><p><strong>Methods: </strong>The following databases were searched: PubMed and Web of Science.</p><p><strong>Results and conclusion: </strong>Foreign allergens include allergenic proteins and chemical haptens. This review summarizes the various methods used for designing animal models of common allergenic protein-induced type I hypersensitivity, namely, passive anaphylaxis model, active systemic anaphylaxis/anaphylaxis shock model, food allergy model, asthma model, and IgE-mediated cell models. Additionally, we summarize shrimp tropomyosin-induced type I hypersensitivity models from our previous studies and discuss their advantages and limitations compared with that of ovalbumin-induced models.</p>\",\"PeriodicalId\":73062,\"journal\":{\"name\":\"Frontiers in allergy\",\"volume\":\"5 \",\"pages\":\"1481011\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525013/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in allergy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/falgy.2024.1481011\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/falgy.2024.1481011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
摘要
背景:全球约有三分之一的人患有 I 型超敏反应。由于 I 型超敏反应(哮喘、食物过敏和过敏性休克等)的病理生理学十分复杂且具有异质性,因此动物模型研究仍然是确定新型分子通路和提供治疗策略的关键:选择动物模型时应仔细考虑方案变量、动物种类和品系,以准确反映人类的典型临床症状:方法:检索了以下数据库:PubMed 和 Web of Science:结果和结论:外来过敏原包括过敏性蛋白质和化学过敏原。本综述总结了设计常见过敏原蛋白诱导的 I 型超敏反应动物模型的各种方法,即被动过敏性休克模型、主动全身过敏性休克/过敏性休克休克模型、食物过敏模型、哮喘模型和 IgE 介导的细胞模型。此外,我们还总结了以往研究中虾肌球蛋白诱导的 I 型超敏反应模型,并讨论了它们与卵清蛋白诱导模型相比的优势和局限性。
Allergenic protein-induced type I hypersensitivity models: a review.
Context: Type I hypersensitivity affects approximately one-third of the global population. As the pathophysiology underlying the development of type I hypersensitivity (asthma, food allergy, and anaphylactic shock, etc.) is complex and heterogeneous, animal model studies continue to be the key to identifying novel molecular pathways and providing therapeutic strategies.
Objective: Selection of the animal model should be done with careful consideration of the protocol variables, animal species, and strains to accurately reflect the clinical symptoms typical of humans.
Methods: The following databases were searched: PubMed and Web of Science.
Results and conclusion: Foreign allergens include allergenic proteins and chemical haptens. This review summarizes the various methods used for designing animal models of common allergenic protein-induced type I hypersensitivity, namely, passive anaphylaxis model, active systemic anaphylaxis/anaphylaxis shock model, food allergy model, asthma model, and IgE-mediated cell models. Additionally, we summarize shrimp tropomyosin-induced type I hypersensitivity models from our previous studies and discuss their advantages and limitations compared with that of ovalbumin-induced models.