过敏原蛋白诱导的 I 型超敏反应模型:综述。

IF 3.3 Q2 ALLERGY Frontiers in allergy Pub Date : 2024-10-17 eCollection Date: 2024-01-01 DOI:10.3389/falgy.2024.1481011
Yanhua Feng, Liangyu Xu, Jinming Zhang, Jinlian Bin, Xialing Pang, Sheng He, Lei Fang
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引用次数: 0

摘要

背景:全球约有三分之一的人患有 I 型超敏反应。由于 I 型超敏反应(哮喘、食物过敏和过敏性休克等)的病理生理学十分复杂且具有异质性,因此动物模型研究仍然是确定新型分子通路和提供治疗策略的关键:选择动物模型时应仔细考虑方案变量、动物种类和品系,以准确反映人类的典型临床症状:方法:检索了以下数据库:PubMed 和 Web of Science:结果和结论:外来过敏原包括过敏性蛋白质和化学过敏原。本综述总结了设计常见过敏原蛋白诱导的 I 型超敏反应动物模型的各种方法,即被动过敏性休克模型、主动全身过敏性休克/过敏性休克休克模型、食物过敏模型、哮喘模型和 IgE 介导的细胞模型。此外,我们还总结了以往研究中虾肌球蛋白诱导的 I 型超敏反应模型,并讨论了它们与卵清蛋白诱导模型相比的优势和局限性。
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Allergenic protein-induced type I hypersensitivity models: a review.

Context: Type I hypersensitivity affects approximately one-third of the global population. As the pathophysiology underlying the development of type I hypersensitivity (asthma, food allergy, and anaphylactic shock, etc.) is complex and heterogeneous, animal model studies continue to be the key to identifying novel molecular pathways and providing therapeutic strategies.

Objective: Selection of the animal model should be done with careful consideration of the protocol variables, animal species, and strains to accurately reflect the clinical symptoms typical of humans.

Methods: The following databases were searched: PubMed and Web of Science.

Results and conclusion: Foreign allergens include allergenic proteins and chemical haptens. This review summarizes the various methods used for designing animal models of common allergenic protein-induced type I hypersensitivity, namely, passive anaphylaxis model, active systemic anaphylaxis/anaphylaxis shock model, food allergy model, asthma model, and IgE-mediated cell models. Additionally, we summarize shrimp tropomyosin-induced type I hypersensitivity models from our previous studies and discuss their advantages and limitations compared with that of ovalbumin-induced models.

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CiteScore
2.80
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审稿时长
12 weeks
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