时间依赖性视网膜电图、代谢组学和脂质组学筛选出代谢标记物,用于从头开始监测糖尿病视网膜病变的过程。

IF 3.1 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Acta Diabetologica Pub Date : 2024-11-01 DOI:10.1007/s00592-024-02336-8
Yue Tian, Yan-Ling Liu, Qian Wang, Ming-Shuang Wang, Ya-Hong Chen, Hong-Juan Wang, Jian-Mei Huang
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引用次数: 0

摘要

目的:糖尿病视网膜病变(DR)是糖尿病(DM)的一种严重并发症,用传统方法很难在早期诊断出 DR。本研究旨在提出一种从头开始监测糖尿病视网膜病变过程的创新方法:方法:通过时间依赖性代谢组学和脂质组学获得随DM变化的血浆代谢物;通过视网膜电图(ERG)的b波振幅和总Ops波振幅测量视网膜功能的变化。通过多变量统计分析、逻辑回归和相关分析,从代谢物中找出用于监测DR的代谢标记物,并研究代谢标记物与视网膜功能之间的关系:结果:与DR相关的代谢标志物LPE18:0、LPC15:0、SM d14:2/26:0、SM d12:0/28:2和MG 21:0可作为代谢标志物监测DR的进程;肌醇和LPC22:5的减少以及木糖酸和TAG10:0/16:0/18:1的增加表明视网膜功能障碍:代谢标志物的水平可用作 DR 发病的指标或监测视网膜功能变化的手段。
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Time-dependent electroretinogram, metabolomics and lipidomics screened metabolic markers for monitoring the process of diabetic retinopathy from scratch.

Aims: Diabetic retinopathy (DR) is a severe complication of diabetes mellitus (DM), and it is challenging to diagnose DR at an early stage by conventional methods. The aim of the present work is to propose an innovative approach to monitor the process of DR from scratch.

Methods: The plasma metabolites changed with DM were obtained by time-dependent metabolomics and lipidomics; the change of retinal function was measured by b-wave amplitude and total Ops-wave amplitude in electroretinography (ERG). Multivariate statistical analysis, logistic regression and correlation analysis were employed to identify metabolic markers from metabolites for the monitoring of DR and investigate the relationship between metabolic markers and retinal function.

Results: The metabolic markers LPE18:0, LPC15:0, SM d14:2/26:0, SM d12:0/28:2 and MG 21:0 associated with DR can be utilized as metabolic markers to monitor the process of DR; The decrease in myo-inositol and LPC22:5 and increase in xylonic acid and TAG10:0/16:0/18:1 indicated retinal dysfunction.

Conclusions: The levels of metabolic markers can be used as an indicator of the onset of DR or as a means of monitoring changes in retinal function.

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来源期刊
Acta Diabetologica
Acta Diabetologica 医学-内分泌学与代谢
CiteScore
7.30
自引率
2.60%
发文量
180
审稿时长
2 months
期刊介绍: Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.
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