2020 年 1 月至 2022 年 8 月居住在加拿大的成年人 COVID-19 后病情发展、严重程度和缓解的相关因素。

IF 2.9 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-11-01 DOI:10.17269/s41997-024-00958-7

Dianne Zakaria, Alain Demers, Nicholas Cheta, Samina Aziz, Peri Abdullah

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Multivariable modeling using confirmed cases identified associated factors.Results: As of August 2022, 17.2% (95% CI 15.7, 18.8) of adults with confirmed infections and 16.7% (95% CI 15.5, 18.0) of adults with confirmed or suspected infections experienced PCC, translating to 3.3% (95% CI 3.0, 3.6) and 4.4% (95% CI 4.1, 4.8) of all adults, respectively. Age less than 65 years (aORs of 1.75 to 2.14), more pre-existing comorbidities (aORs of 1.75 to 3.57), and a more severe initial infection (aORs of 3.52 to 9.69) were all associated with higher odds of PCC, while male sex at birth (aOR = 0.54, 95% CI 0.41, 0.70), identifying as Black (aOR = 0.23, 95% CI 0.11, 0.51), and being infected after 2020 (aORs of 0.24 to 0.55) were associated with lower odds. 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引用次数: 0

摘要

目的我们旨在描述加拿大成年人 COVID-19 后病情（PCC）的负担特征，并确定与病情发生、严重程度和缓解相关的因素：我们使用了 2022 年 4 月至 8 月期间对加拿大成年人进行的基于人口的横断面概率调查中的自我报告数据。我们使用确诊感染以及确诊和疑似合并感染来估算 PCC 的发病率和流行率。利用确诊病例建立的多变量模型确定了相关因素：截至 2022 年 8 月，17.2%（95% CI 15.7，18.8）的确诊感染成人和 16.7%（95% CI 15.5，18.0）的确诊或疑似感染成人经历了 PCC，分别占所有成人的 3.3%（95% CI 3.0，3.6）和 4.4%（95% CI 4.1，4.8）。年龄小于 65 岁（aORs 为 1.75 至 2.14）、原有合并症较多（aORs 为 1.75 至 3.57）、初始感染较严重（aORs 为 3.52 至 9.69）都与 PCC 的发生几率较高有关，而出生时性别为男性（aOR = 0.54，95% CI 0.41，0.70）、确定为黑人（aOR = 0.23，95% CI 0.11，0.51）和 2020 年后感染（aORs 0.24 至 0.55）与较低的几率相关。居住在农村地区（aOR = 2.31，95% CI 1.35，3.93），或报告有残疾（aOR = 2.87，95% CI 1.14，7.25）、原有慢性肺部疾病（aOR = 5.47，95% CI 1.85，16.12）或背部问题（aOR = 2.34，95% CI 1.26，4.36），或 PCC 头痛（aOR = 2.47，95% CI 1.60，3.83）或乏力（aOR = 2.27，95% CI 1.41，3.68）的患者在日常活动中受到更大限制的几率更高，而男性患者的几率较低（aOR = 0.54，95% CI 0.34，0.85）。两个或两个以上的原有慢性疾病（aHR 从 0.33 到 0.38），或与心脏（aHR = 0.25，95% CI 0.07，0.90）、脑雾（aHR = 0.44，95% CI 0.23，0.86）或压力/焦虑（aHR = 0.48，95% CI 0.24，0.96）有关的 PCC 症状与症状缓解率降低有关：结论：在流感大流行的头两年半时间里，加拿大相当一部分受感染的成年人报告了 PCC。女性和合并症患者受到的影响尤为严重。

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Factors associated with the development, severity, and resolution of post COVID-19 condition in adults living in Canada, January 2020 to August 2022.

Objectives: We aimed to characterize the burden of post COVID-19 condition (PCC) among adults in Canada and identify factors associated with its occurrence, severity, and resolution.

Methods: We used self-report data from a population-based cross-sectional probability survey of adults in Canada conducted between April and August 2022. Incidence and prevalence of PCC were estimated using confirmed infections, as well as confirmed and suspected combined. Multivariable modeling using confirmed cases identified associated factors.

Results: As of August 2022, 17.2% (95% CI 15.7, 18.8) of adults with confirmed infections and 16.7% (95% CI 15.5, 18.0) of adults with confirmed or suspected infections experienced PCC, translating to 3.3% (95% CI 3.0, 3.6) and 4.4% (95% CI 4.1, 4.8) of all adults, respectively. Age less than 65 years (aORs of 1.75 to 2.14), more pre-existing comorbidities (aORs of 1.75 to 3.57), and a more severe initial infection (aORs of 3.52 to 9.69) were all associated with higher odds of PCC, while male sex at birth (aOR = 0.54, 95% CI 0.41, 0.70), identifying as Black (aOR = 0.23, 95% CI 0.11, 0.51), and being infected after 2020 (aORs of 0.24 to 0.55) were associated with lower odds. Those residing in a rural area (aOR = 2.31, 95% CI 1.35, 3.93), or reporting a disability (aOR = 2.87, 95% CI 1.14, 7.25), pre-existing chronic lung condition (aOR = 5.47, 95% CI 1.85, 16.12) or back problem (aOR = 2.34, 95% CI 1.26, 4.36), or PCC headache (aOR = 2.47, 95% CI 1.60, 3.83) or weakness (aOR = 2.27, 95% CI 1.41, 3.68) had higher odds of greater limitations in daily activities, while males had lower odds (aOR = 0.54, 95% CI 0.34, 0.85). Two or more pre-existing chronic conditions (aHRs from 0.33 to 0.38), or PCC symptoms relating to the heart (aHR = 0.25, 95% CI 0.07, 0.90), brain fog (aHR = 0.44, 95% CI 0.23, 0.86), or stress/anxiety (aHR = 0.48, 95% CI 0.24, 0.96) were associated with a decreased rate of symptom resolution.

Conclusion: Over the first two and a half years of the pandemic, a substantial proportion of infected adults in Canada reported PCC. Females and people with comorbidities were disproportionately impacted.

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来源期刊

Canadian Journal of Public Health-Revue Canadienne De Sante Publique PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

6.10

自引率

4.70%

发文量

128

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