2020 年至 2022 年巴西亚马逊地区研究中心医护人员感染 SARS-CoV-2 的临床、流行病学和分子特征。

IF 2.1 4区 生物学 Q3 MICROBIOLOGY Brazilian Journal of Microbiology Pub Date : 2024-11-01 DOI:10.1007/s42770-024-01557-x
Darciane Coelho Cordovil, Delana Andreza Melo Bezerra, Rayssa Layna Silva Bedran, Edvaldo Tavares Penha Junior, Dielle Monteiro Teixeira, Patricia Santos Lobo, Jones Anderson Monteiro Siqueira, Adinaura Gama Ramos, Amanda Mendes Silva, Kenny Costa Pinheiro, Jedson Cardoso Ferreira, Wanderley Dias Chagas Junior, Luana Soares Barbagelata, Fernando Neto Tavares, Mirleide Cordeiro Santos, Luana Silva Soares
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引用次数: 0

摘要

冠状病毒病-2019(COVID-19)大流行已影响到社会的各个领域,而医护人员受到的影响尤为严重。本研究旨在描述 2020 年 10 月至 2022 年 7 月期间巴西研究参考中心埃万德罗-查格斯研究所医护人员感染 SARS-CoV-2 的临床、流行病学和分子特征。从出现呼吸道感染临床症状的患者中采集了 845 份样本。通过基因组测序提交了鼻咽部阳性样本。对临床、流行病学和 SARS-CoV-2 世系(或变种)进行了分析。31.8%的样本(269/845)检测出 SARS-CoV-2 阳性,其中女性阳性率较高(60.2%)。2021 年 3 月(39%)、2022 年 1 月(65%)和 2022 年 7 月(56%)的 SARS-CoV-2 阳性率最高。在临床症状方面,2020 年的关节痛、发冷和腹泻有显著统计学意义;2021 年的发烧、流鼻涕和关节痛;2022 年的流鼻涕和咳嗽有显著统计学意义。在对 SARS-CoV-2 进行分子分析时,对 66 个样本(66/269,占 25.3%)进行了测序,其中最普遍的品系是 Omicron,占 57.6%。由于研究中心在识别和监测传染病的监测工作中发挥着重要作用,因此对高危工作人群的流行病学和临床特征进行研究对于提出控制措施和工作管理至关重要。
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Clinical, epidemiological, and molecular characteristics of SARS-CoV-2 Infections among healthcare workers at a research center in the amazon region of BRAZIL from 2020 to 2022.

The coronavirus disease-2019 (COVID-19) pandemic has affected different sectors of society, and healthcare workers have been particularly impacted. This study aimed to describe the clinical, epidemiological, and molecular characteristics of SARS-CoV-2 infections among healthcare workers in Evandro Chagas Institute, a research reference center in Brazil, from October 2020 to July 2022. 845 samples were collected from individuals who presented clinical symptoms of respiratory infection. Nasopharyngeal positive samples were submitted through genome sequencing. Clinical, epidemiological, and the SARS-CoV-2 lineages (or variants) were analyzed. SARS-CoV-2 positivity was detected in 31.8% (269/845) of samples with a higher prevalence of females (60.2%). The highest SARS-CoV-2 positivity rates were reported in March 2021 (39%), January 2022 (65%), and July 2022 (56%). On clinical symptoms, arthralgia, chills, and diarrhea were statistically significantly detected in 2020; fever, runny nose, and arthralgia in 2021; runny nose, and cough in 2022. On molecular analysis of SARS-CoV-2, 66 samples (25.3%, 66/269) were sequenced and the most prevalent lineage was the Omicron, representing 57.6%. Studies on the epidemiological and clinical characteristics of HCW are essential to propose control measures and work management since research centers play a major role in surveillance to identify and monitor infectious diseases.

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来源期刊
Brazilian Journal of Microbiology
Brazilian Journal of Microbiology 生物-微生物学
CiteScore
4.10
自引率
4.50%
发文量
216
审稿时长
1.0 months
期刊介绍: The Brazilian Journal of Microbiology is an international peer reviewed journal that covers a wide-range of research on fundamental and applied aspects of microbiology. The journal considers for publication original research articles, short communications, reviews, and letters to the editor, that may be submitted to the following sections: Biotechnology and Industrial Microbiology, Food Microbiology, Bacterial and Fungal Pathogenesis, Clinical Microbiology, Environmental Microbiology, Veterinary Microbiology, Fungal and Bacterial Physiology, Bacterial, Fungal and Virus Molecular Biology, Education in Microbiology. For more details on each section, please check out the instructions for authors. The journal is the official publication of the Brazilian Society of Microbiology and currently publishes 4 issues per year.
期刊最新文献
Clinical, epidemiological, and molecular characteristics of SARS-CoV-2 Infections among healthcare workers at a research center in the amazon region of BRAZIL from 2020 to 2022. Peritonitis-related bacterial infections: a large-scale case-series retrospective study in 160 domestic animals (2009-2022). High release of Candida albicans eDNA as protection for the scaffolding of polymicrobial biofilm formed with Staphylococcus aureus and Streptococcus mutans against the enzymatic activity of DNase I. Anti-quorum sensing activity of essential oils against multidrug-resistant Klebsiella pneumoniae: a novel approach to control bacterial virulence. Isolation of marine-derived filamentous fungi and their potential application for bioremediation process.
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