童年遭受虐待与日后遭受亲密伴侣暴力侵害之间的因果关系和共同风险途径

IF 9.6 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Psychiatry Pub Date : 2024-11-02 DOI:10.1038/s41380-024-02813-0
Patrizia Pezzoli, Jean-Baptiste Pingault, Thalia C. Eley, Eamon McCrory, Essi Viding
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引用次数: 0

摘要

童年虐待和亲密伴侣暴力(IPV)受害是主要的精神疾病风险因素。虐待会大大增加随后成为 IPV 受害者的可能性,但这种关联的驱动因素却鲜为人知。我们采用定量遗传学方法分析了双胞胎早期发育研究(Twins Early Development Study)中 12,794 名参与者(58% 为女性,42% 为男性)在 21 岁和 26 岁时对虐待和 IPV 受害情况的回顾性自我报告。我们估计了虐待和 IPV 的共同病因影响,以及虐待对 IPV 的影响超出了这些共同影响。报告童年遭受虐待的参与者(约占样本的 7%)在 21 岁时报告遭受 IPV 的可能性是同龄人的 3 倍,在 26 岁时是同龄人的 4 倍。虐待与 IPV 之间的关联主要是由于同卵双胞胎共享的环境影响(42%-43%)和遗传影响(30%-33%)以及非共享的环境影响(25%-27%)造成的。虐待与 IPV 之间的关系在女性和男性中相似,但其病因在一定程度上因性别而异。在表型模型(β = 0.25-0.30)中,虐待对 IPV 有中等程度的影响,而在考虑到二者共同病因的因果信息模型(β = 0.15-0.21)中,虐待对 IPV 的影响降至小到中等程度。虐待和 IPV 受害的共同风险因素主要来自家庭、环境和遗传。即使考虑到常见的风险因素,遭受虐待也可能与随后的 IPV 受害有因果关系。有必要采取干预措施,促进遭受虐待的年轻成年人建立安全的亲密关系,并应解决家庭层面的环境风险和由遗传形成的个人层面的风险。
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Causal and common risk pathways linking childhood maltreatment to later intimate partner violence victimization

Childhood maltreatment and intimate partner violence (IPV) victimization are major psychiatric risk factors. Maltreatment substantially increases the likelihood of subsequent IPV victimization, but what drives this association is poorly understood. We analyzed retrospective self-reports of maltreatment and IPV victimization in 12,794 participants (58% women, 42% men) from the Twins Early Development Study at ages 21 and 26 using quantitative genetic methods. We estimated the etiological influences common to maltreatment and IPV, and the effect of maltreatment on IPV beyond such common influences. Participants who reported childhood maltreatment ( ~ 7% of the sample) were 3 times more likely than their peers to also report IPV victimization at age 21, 4 times more likely at 26. The association between maltreatment and IPV was mostly due to environmental influences shared by co-twins (42–43%) and genetic influences (30–33%), as well as nonshared environmental influences (25–27%). The association between maltreatment and IPV was similar for women and men, but its etiology partly differed by sex. Maltreatment had a moderate effect on IPV in phenotypic models (β = 0.25–0.30), decreasing to a small-to-moderate range in causally informative models accounting for their common etiology (β = 0.15–0.21). Risk factors common to maltreatment and IPV victimization are largely familial in origin, environmental and genetic. Even considering common risk factors, experiencing maltreatment may be causally related to subsequent IPV victimization. Interventions promoting safe intimate relationships among young adults exposed to maltreatment are warranted and should address family-level environmental risk and individual-level risk shaped by genetics.

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来源期刊
Molecular Psychiatry
Molecular Psychiatry 医学-精神病学
CiteScore
20.50
自引率
4.50%
发文量
459
审稿时长
4-8 weeks
期刊介绍: Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.
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