保留放疗下咽癌患者的喉食管功能：预测因素和长期疗效。

IF 2.9 2区医学 Q2 ONCOLOGY Cancer Medicine Pub Date : 2024-11-02 DOI:10.1002/cam4.70374

Aya Nakajima, Michio Yoshimura, Shinya Hiraoka, Ryota Nakashima, Yo Kishimoto, Koichi Omori, Takashi Mizowaki

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引用次数: 0

摘要

背景：下咽癌（HPC）治疗后的功能结果对患者的生活质量和预后有重要影响。本研究旨在确定接受明确放疗的下咽癌患者喉食道功能障碍的相关预测因素：对 2007 年至 2019 年期间在我院接受确定性调强放疗的 HPC 患者进行了回顾性评估。无喉食管功能障碍生存（LDFS）事件定义为局部复发、喉食管功能障碍（定义为气管造口术或喂食管依赖）或任何原因导致的死亡：80名患者的中位随访时间为61个月。5年LDFS率为47%。临床T4分期和治疗前较低的预后营养指数（PNI）与较低的LDFS独立相关：结论：临床T4分期和治疗前较低的营养指数被认为是HPC明确放疗后较低LDFS的预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Preserving Laryngo-Esophageal Function in Patients With Hypopharyngeal Cancer Treated With Radiotherapy: Predictive Factors and Long-Term Outcomes

Background

Functional outcomes after hypopharyngeal cancer (HPC) treatment have a significant effect on patients' quality of life and prognosis. This study aimed to identify the predictive factors associated with laryngo-esophageal dysfunction in patients with HPC who received definitive radiotherapy.

Methods

Patients with HPC treated with definitive intensity-modulated radiotherapy between 2007 and 2019 at our institution were retrospectively evaluated. Laryngo-esophageal dysfunction-free survival (LDFS) events were defined as local recurrence, laryngo-esophageal dysfunction (defined as tracheostomy or feeding tube dependence), or death from any cause.

Results

The median follow-up period was 61 months for the 80 patients included in the study. The 5-year LDFS rate was 47%. A clinical T4 stage and lower pretreatment prognostic nutritional index (PNI) were independently associated with a lower LDFS.

Conclusion

A clinical T4 stage and lower pretreatment PNI were identified as predictors of a lower LDFS after definitive radiotherapy for HPC.

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.