炎症性肠病的亚临床淀粉样沉积:两家医院的研究

IF 2.9 4区 医学 Q2 PATHOLOGY Pathology, research and practice Pub Date : 2024-10-28 DOI:10.1016/j.prp.2024.155682
Yuichiro Hamamoto , Kansuke Kido , Michihiro Kawamura , Yuki Sekido , Takayuki Ogino , Hironao Yasuoka , Hideki Iijima , Tsunekazu Mizushima
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引用次数: 0

摘要

炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC),主要影响年轻患者并导致肠道并发症。淀粉样变性涉及异常蛋白质沉积,是 IBD 的一种严重并发症,但发病率较低。早期发现亚临床淀粉样变性沉积对预防致命后果至关重要,但目前缺乏常规检查。我们的目的是回顾性研究成年 IBD 患者的亚临床淀粉样沉积。我们从两家医院的数据库中收集了 249 名 IBD 患者的手术标本。对标本进行染色和免疫组化,并同时收集临床信息。根据刚果红染色,CD(1/131)和 UC(0/118)的淀粉样蛋白阳性率分别为 0.8%和 0%。淀粉样蛋白沉积患者是一名80多岁的女性,没有淀粉样变性家族史。亚型为淀粉样蛋白A。临床病史显示,她在30多岁时进行过肠道切除术,随后出现腹部症状。据我们所知,这是第一项从患有 CD 或 UC 的成人中收集超过 100 份手术检查标本的研究。对于临床病程长且复杂的老年患者,积极分析淀粉样蛋白会更好。
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Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), predominantly affects young patients and leads to intestinal complications. Amyloidosis, which involves abnormal protein deposition, is a serious complication of IBD, with a low incidence. Early detection of subclinical amyloid deposits is crucial for preventing fatal outcomes; however, routine investigations are lacking. We aimed to retrospectively examine subclinical amyloid deposition in adult patients with IBD. Surgical specimens from 249 patients with IBD were collected from the databases of two hospitals. The specimens were subjected to staining and immunohistochemistry, and clinical information was collected simultaneously. The amyloid positivity rate was 0.8 % in CD (1/131) and 0 % in UC (0/118) based on Congo red staining. The patient with amyloid deposits was a female in her 80 s who lacked a family history of amyloidosis. The subtype was amyloid A. Clinical history revealed intestinal resection in her 30 s and subsequent abdominal symptoms. To the best of our knowledge, this is the first study to collect >100 surgically examined specimens from adults with CD or UC. In older patients with a long and complex clinical course, aggressive analysis of amyloids would be better.
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来源期刊
CiteScore
5.00
自引率
3.60%
发文量
405
审稿时长
24 days
期刊介绍: Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.
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