微(纳米)塑料:人类健康的新负担。

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.99556
Isabella Donisi, Antonino Colloca, Camilla Anastasio, Maria Luisa Balestrieri, Nunzia D'Onofrio
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引用次数: 0

摘要

塑料污染的加剧是一个全球性的环境和健康问题。塑料降解过程中产生的微塑料(MPs)和纳米塑料(NPs)不断扩散,产生了重要的毒性影响。这些微粒在环境中无处不在,人类通过摄入、吸入和皮肤接触等方式不断接触到它们。然而,微塑料和纳米塑料(MNPs)对人体健康造成的细胞平衡失调最近才被证实,而大多数证据和分子机制都来自体外和体内模型研究。迄今为止,大多数现有结果都证明了 MNPs 在心血管、神经、生殖和消化系统中的蓄积,最近还提供了有关 MNPs 对人类心血管毒性影响的明确证据。在此背景下,本综述旨在全面更新报告 MNPs 在不同模型中影响的最新研究,重点关注与人类健康相关的主要研究领域的现有证据。希望本综述有助于提高人们对 MNPs 的毒性和氧化作用的认识,从而支持制定应对塑料流行病的新策略。
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Micro(nano)plastics: an Emerging Burden for Human Health.

The escalation of plastic pollution represents a global environmental and health problem. Important toxic effects have been attributed to the increasing diffusion of microplastics (MPs) and nanoplastics (NPs) derived from the degradation of plastics. These particles have been ubiquitously observed in the environment, with humans being continuously exposed via ingestion, inhalation and skin contact. Nonetheless, the cellular homeostasis imbalance induced by micro- and nano- plastics (MNPs) in human health has been only recently shown, while most evidence and molecular mechanisms derived from studies in vitro and in vivo models. To date, the majority of available results testified the accumulation of MNPs in the cardiovascular, nervous, reproductive and digestive systems, and recently clear evidence about cardiovascular toxic effects of MNPs has been provided in humans. In this context, this review aims to provide a comprehensive update about the most recent studies reporting the effects of MNPs in different models, focusing on the available evidence in the main areas of study related to human health. Hopefully, this review will contribute to raise awareness about the toxicity and oxidative alteration exerted by MNPs, supporting the elaboration of new strategies to counteract plastic pandemics.

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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
期刊最新文献
Targeting mitochondria by lipid-selenium conjugate drug results in malate/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression. Mechanistic study of celastrol-mediated inhibition of proinflammatory activation of macrophages in IgA nephropathy via down-regulating ECM1. Micro(nano)plastics: an Emerging Burden for Human Health. New insights into non-small cell lung cancer bone metastasis: mechanisms and therapies. SUMOylation modification of HNRNPK at the K422 site promotes invasion in glioblastoma.
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