用二苯乙烯类药物治疗神经系统疾病:弥合临床前与临床之间的差距。

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.102032
Md Zamshed Alam Begh, Jishan Khan, Mehrukh Zehravi, Sherouk Hussein Sweilam, A Dinesh Raja, A Muthukumar, M Akiful Haque, Nihar Ranjan Kar, Laliteshwar Pratap Singh, B Dharani Priya, Mohammed Ali Alshehri, Irfan Ahmad, Sojin Kang, Seungjoon Moon, Moon Nyeo Park, Talha Bin Emran, Bonglee Kim
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引用次数: 0

摘要

神经系统疾病(NDs)包括一系列影响神经系统的衰弱性疾病,其中包括阿尔茨海默病、帕金森病和缺血性中风等常见疾病。尽管目前正在进行大量研究,但仍缺乏有效的治疗策略来阻止或减缓这些疾病的发展。芪类是一类天然多酚类化合物,由于具有保护神经系统的能力,已显示出作为治疗策略候选物质的潜力。临床前研究已经提供了强有力的证据,证明二苯乙烯类化合物可以调节许多与神经退行性病变有关的细胞通路,其中白藜芦醇是一种经过充分研究的化合物,它能够减少氧化损伤、促进神经发生和增强线粒体功能--这对维持大脑健康至关重要。在临床前动物模型中,初步研究还显示了其他物质的前景,如皮脂醇和紫檀芪。此外,临床研究还探索了二苯乙烯类化合物对 NDs 的治疗效果。尽管临床前研究取得了可喜的成果,但目前在临床试验中使用的二苯乙烯类化合物还很有限,大多数研究都集中在白藜芦醇上。虽然有几项临床研究表明补充白藜芦醇对大脑健康和退行性后果有益,但其他调查的结果并不明确,这说明迫切需要进行更全面、更精确规划的临床研究。本研究探讨了二苯乙烯类化合物作为神经保护剂对 NDs 的潜在益处。它强调了进行更多临床研究的必要性,以加深我们对其在特定患者群体中治疗效果的了解。
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Targeting Neurological Disorders with Stilbenes: Bridging the Preclinical-Clinical Gap.

Neurological disorders (NDs) encompass a range of debilitating conditions that affect the nervous system, including prevalent illnesses such as Alzheimer's disease, Parkinson's disease, and ischemic stroke. Despite significant ongoing studies, effective therapeutic strategies to halt or slow down the progression of these illnesses are still lacking. Stilbenes, a class of natural polyphenols, have shown potential as candidates for therapeutic strategies due to their capacity to protect the nervous system. Preclinical studies have provided strong evidence that stilbenes can regulate many cellular pathways implicated in neurodegeneration, with resveratrol being a well-studied compound that has shown the ability to reduce oxidative damage, promote neurogenesis, and enhance mitochondrial function - crucial for maintaining brain health. In preclinical animal models, initial research has also shown promise in additional substances such as piceatannol and pterostilbene. Furthermore, clinical studies have explored the therapeutic benefits of stilbenes in NDs. Despite promising results in preclinical research, the use of stilbenes in clinical trials is currently limited, with most studies focusing on resveratrol. Although several clinical studies have demonstrated the beneficial impact of resveratrol supplementation on brain health and degenerative consequences, other investigations have yielded ambiguous findings, underscoring the urgent need for more comprehensive and precisely planned clinical research. This study delves into the potential benefits of stilbenes as neuroprotective agents for NDs. It emphasizes the need for more clinical research to enhance our understanding of their therapeutic effectiveness in specific patient groups.

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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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