Maddalena Ruggieri, Giulia Paparella, Livio Clemente, Giuseppe Libro, Concetta Domenica Gargano, Marina de Tommaso
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All patients were also assessed with clinical scales examining fibromyalgia disability, sleep quality and duration, fatigue, anxiety, and depression, and a neuropsychological battery examining executive function, verbal short-term memory, and working memory, as well as attentional executive function and selective attention, interference sensitivity, and inhibition of automatic responses.</p><p><strong>Results: </strong>NFL levels were higher in FM patients (controls 6.19± 1.92; FM 17.28± 15.94 pg/mL ANOVA p 0.002). Working memory was the most impaired cognitive function significantly correlated with high NFL scores (Pearson p 0.034). Short sleep times also correlated with higher NFL scores (Pearson p 0.02) and poorer working memory performance (Pearson p 0.02). No correlation was found with indices of disease severity and duration.</p><p><strong>Conclusions: </strong>Plasma NFL levels are elevated in fibromyalgia patients, suggesting neuronal damage and correlating with a slight decrease in working memory and short sleep duration.</p><p><strong>Significance statement: </strong>Plasma neurofilament levels are elevated in patients with fibromyalgia, regardless of disease severity and duration. Neurofilament levels are higher in patients with mild working memory impairment and sleep disorders. Subgroups of patients with primary neuronal damage phenomena could be individualized for prospective evaluation with regard to the possible development of cognitive decline and sleep disturbances, which would justify a tailored therapeutic approach.</p>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Plasma neurofilament light chain in fibromyalgia: A case control study exploring correlation with clinical and cognitive features.\",\"authors\":\"Maddalena Ruggieri, Giulia Paparella, Livio Clemente, Giuseppe Libro, Concetta Domenica Gargano, Marina de Tommaso\",\"doi\":\"10.1002/ejp.4752\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Plasma neurofilament light chain (NFL) has been measured as a biomarker of neuronal damage in various neurological disorders. Elevated tau and β-amyloid levels have been found in patients with fibromyalgia (FM). The aim of the present study was to compare plasma neurofilament levels in fibromyalgia patients with normal controls and to investigate the correlation with clinical features and cognitive tests.</p><p><strong>Methods: </strong>Plasma NFL levels were assessed in 33 FM patients and compared with 22 age-matched controls. All patients were also assessed with clinical scales examining fibromyalgia disability, sleep quality and duration, fatigue, anxiety, and depression, and a neuropsychological battery examining executive function, verbal short-term memory, and working memory, as well as attentional executive function and selective attention, interference sensitivity, and inhibition of automatic responses.</p><p><strong>Results: </strong>NFL levels were higher in FM patients (controls 6.19± 1.92; FM 17.28± 15.94 pg/mL ANOVA p 0.002). Working memory was the most impaired cognitive function significantly correlated with high NFL scores (Pearson p 0.034). Short sleep times also correlated with higher NFL scores (Pearson p 0.02) and poorer working memory performance (Pearson p 0.02). No correlation was found with indices of disease severity and duration.</p><p><strong>Conclusions: </strong>Plasma NFL levels are elevated in fibromyalgia patients, suggesting neuronal damage and correlating with a slight decrease in working memory and short sleep duration.</p><p><strong>Significance statement: </strong>Plasma neurofilament levels are elevated in patients with fibromyalgia, regardless of disease severity and duration. Neurofilament levels are higher in patients with mild working memory impairment and sleep disorders. 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引用次数: 0
摘要
背景:血浆神经丝蛋白轻链(NFL)已被测定为各种神经系统疾病中神经元损伤的生物标志物。在纤维肌痛(FM)患者中发现 tau 和 β 淀粉样蛋白水平升高。本研究旨在比较纤维肌痛患者与正常对照组的血浆神经丝蛋白水平,并研究其与临床特征和认知测试的相关性:方法:对 33 名纤维肌痛患者的血浆神经丝蛋白水平进行评估,并与 22 名年龄匹配的对照组进行比较。所有患者还接受了纤维肌痛残疾、睡眠质量和持续时间、疲劳、焦虑和抑郁等临床量表评估,以及执行功能、言语短期记忆和工作记忆、注意执行功能和选择性注意、干扰敏感性和自动反应抑制等神经心理测试:FM患者的NFL水平更高(对照组为6.19± 1.92;FM为17.28± 15.94 pg/mL ANOVA p 0.002)。工作记忆是认知功能受损最严重的一项,与高 NFL 分数显著相关(Pearson p 0.034)。睡眠时间短也与较高的 NFL 分数(Pearson p 0.02)和较差的工作记忆能力(Pearson p 0.02)相关。结论:血浆 NFL 水平的升高与心血管疾病的严重程度和持续时间有关:结论:纤维肌痛患者的血浆神经丝蛋白水平升高,表明神经元受损,并与工作记忆和短睡眠时间的轻微下降相关:纤维肌痛患者的血浆神经丝蛋白水平升高,与疾病的严重程度和持续时间无关。轻度工作记忆障碍和睡眠障碍患者的神经丝水平较高。可以对具有原发性神经元损伤现象的亚组患者进行个体化的前瞻性评估,以了解其可能出现的认知能力下降和睡眠障碍,从而有理由采取有针对性的治疗方法。
Plasma neurofilament light chain in fibromyalgia: A case control study exploring correlation with clinical and cognitive features.
Background: Plasma neurofilament light chain (NFL) has been measured as a biomarker of neuronal damage in various neurological disorders. Elevated tau and β-amyloid levels have been found in patients with fibromyalgia (FM). The aim of the present study was to compare plasma neurofilament levels in fibromyalgia patients with normal controls and to investigate the correlation with clinical features and cognitive tests.
Methods: Plasma NFL levels were assessed in 33 FM patients and compared with 22 age-matched controls. All patients were also assessed with clinical scales examining fibromyalgia disability, sleep quality and duration, fatigue, anxiety, and depression, and a neuropsychological battery examining executive function, verbal short-term memory, and working memory, as well as attentional executive function and selective attention, interference sensitivity, and inhibition of automatic responses.
Results: NFL levels were higher in FM patients (controls 6.19± 1.92; FM 17.28± 15.94 pg/mL ANOVA p 0.002). Working memory was the most impaired cognitive function significantly correlated with high NFL scores (Pearson p 0.034). Short sleep times also correlated with higher NFL scores (Pearson p 0.02) and poorer working memory performance (Pearson p 0.02). No correlation was found with indices of disease severity and duration.
Conclusions: Plasma NFL levels are elevated in fibromyalgia patients, suggesting neuronal damage and correlating with a slight decrease in working memory and short sleep duration.
Significance statement: Plasma neurofilament levels are elevated in patients with fibromyalgia, regardless of disease severity and duration. Neurofilament levels are higher in patients with mild working memory impairment and sleep disorders. Subgroups of patients with primary neuronal damage phenomena could be individualized for prospective evaluation with regard to the possible development of cognitive decline and sleep disturbances, which would justify a tailored therapeutic approach.
期刊介绍:
European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered.
Regular sections in the journal are as follows:
• Editorials and Commentaries
• Position Papers and Guidelines
• Reviews
• Original Articles
• Letters
• Bookshelf
The journal particularly welcomes clinical trials, which are published on an occasional basis.
Research articles are published under the following subject headings:
• Neurobiology
• Neurology
• Experimental Pharmacology
• Clinical Pharmacology
• Psychology
• Behavioural Therapy
• Epidemiology
• Cancer Pain
• Acute Pain
• Clinical Trials.