利用多酚的抗炎特性治疗炎症性肠病。

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.98107
Diego Liviu Boaru, Oscar Fraile-Martinez, Diego De Leon-Oliva, Cielo Garcia-Montero, Patricia De Castro-Martinez, Alejandro Miranda-Gonzalez, Miguel A Saez, Leticia Muñon-Zamarron, Elisa Castillo-Ruiz, Silvestra Barrena-Blázquez, Rafael Cañonez-Zafra, Miguel Ángel Alvarez-Mon, Maria V Toledo-Lobo, Ana M Minaya-Bravo, Laura Lopez-Gonzalez, Raul Diaz-Pedrero, Jose V Saz, Agustin Albillos, Melchor Alvarez-Mon, Luis G Guijarro, Miguel A Ortega
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引用次数: 0

摘要

炎症性肠病(IBD)包括一系列影响胃肠道的慢性炎症,尤其是溃疡性结肠炎(UC)和克罗恩病(CD)。溃疡性结肠炎和克罗恩病都是遗传和环境因素相互作用的结果,这些因素会引发针对肠道微生物的免疫反应加剧,导致肠道特定区域粘膜的炎症损伤无法缓解。尽管进行了广泛的研究,但目前的治疗方法往往需要进行侵入性干预,对患者的健康造成相当大的不利影响。因此,迫切需要找到替代和辅助治疗策略,以改善慢性炎症并恢复肠道屏障的完整性。多酚是天然形成或作为半合成/合成衍生物的植物性化合物,其促进健康的作用已得到证实,并可转化应用于多种慢性疾病。IBD 的临床前模型在很大程度上支持多种多酚的功效,因为它们对免疫系统和肠道微生物群的抗氧化和调节特性已得到充分证明。同样,越来越多的研究正在人体中使用不同类型的多酚类物质,但仍需做出更多努力。在本综述中,将总结在 IBD 体外和体内模型中研究的主要多酚,以及在人体中可用的试验或观察数据。最后,将讨论多酚在 IBD 临床中的作用,以及有关其转化的主要问题和关注点,包括生物利用度、将其纳入健康饮食模式和食品、与其他药物的相互作用,以及未来研究需要解决的其他重要问题。
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Harnessing the Anti-Inflammatory Properties of Polyphenols in the Treatment of Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD) encompasses a spectrum of chronic inflammatory conditions affecting the gastrointestinal tract, notably ulcerative colitis (UC) and Crohn's disease (CD). Both UC and CD result from the interplay between genetic and environmental factors that trigger an exacerbated immune response against gut microorganisms, leading to non-resolving inflammatory damage in the mucosa of specific zones in the intestine. Despite extensive research, current treatments often entail invasive interventions with considerable adverse effects on patient well-being. Consequently, there is a pressing need to find alternative and complementary therapeutic strategies aimed at ameliorating chronic inflammation and restoring intestinal barrier integrity. Polyphenols are plant-based compounds formed naturally or as semi-synthetic/synthetic derivatives with proven health-promoting effects and translational applications in a broad spectrum of chronic diseases. Preclinical models of IBD largely support the efficacy of a broad variety of polyphenols due to their well-documented antioxidant and modulatory properties on the immune system and gut microbiota. Likewise, a growing number of studies using distinct types of polyphenols are being conducted in humans, although more efforts are still warranted. In the present review, the main polyphenols investigated in vitro and in vivo models of IBD will be summarized, as well as the available trials or observational data accessible in humans. Finally, the role of polyphenols in the clinical context of IBDs, along with the main problematics regarding their translational issues and concerns will be discussed, including bioavailability, their inclusion in healthy dietary patterns and foods, interaction with other drugs, and other important points to be addressed by future research.

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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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