纳他珠单抗治疗的多发性硬化症患者血清神经丝蛋白和胶质纤维酸性蛋白水平与消退症状无关。

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2024-11-04 DOI:10.1177/13524585241293940
Alyssa A Toorop, Mark Hj Wessels, Lynn Boonkamp, Liza My Gelissen, E Hoitsma, Esther Mpe Zeinstra, Luuk C van Rooij, Caspar Ep van Munster, Anke Vennegoor, Jop P Mostert, Beatrijs Ha Wokke, Nynke F Kalkers, Erwin Lj Hoogervorst, Jeroen Jj van Eijk, Christiaan M Roosendaal, Jolijn J Kragt, Marijke Eurelings, Jessie van Genugten, Jessica Nielsen, Lgf Sinnige, Mark E Kloosterziel, Edo Pj Arnoldus, Gert W van Dijk, Willem H Bouvy, Eva Mm Strijbis, Bob W van Oosten, Brigit A de Jong, Bernard Mj Uitdehaag, Theo Rispens, Joep Killestein, Zoé LE van Kempen, Charlotte E Teunissen
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引用次数: 0

摘要

背景:神经元和轴突损伤的生物标志物(血清神经丝蛋白(sNfL)和血清胶质纤维酸性蛋白(sGFAP))可能有助于了解纳他珠单抗耐药症状(WoSs)的病因:我们研究了sNfL和sGFAP与接受纳他珠单抗治疗的多发性硬化症患者出现WoS之间的纵向联系和预测价值:我们对NEXT-MS试验参与者的sNfL和sGFAP进行了纵向测量,这些参与者填写了一份关于WoS的问卷:结果:共纳入364名参与者。在纳他珠单抗治疗期间,共有55.5%的患者出现WoS,44.5%的患者未出现WoS。纵向分析显示,sNfL和sGFAP水平与任何时间点的WoS均无关联。基线生物标志物水平不能预测首次WoS的发生:结论:急性和慢性神经元和轴突损伤很可能不是导致 WoS 的根本原因。
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Serum neurofilament light and glial fibrillary acidic protein levels are not associated with wearing-off symptoms in natalizumab-treated multiple sclerosis patients.

Background: Biomarkers of neuronal and axonal damage (serum neurofilament light (sNfL) and serum glial fibrillary acidic protein (sGFAP)) may provide insight into the aetiology of natalizumab wearing-off symptoms (WoSs).

Objectives: We investigated the longitudinal association between and predictive value of sNfL and sGFAP and the occurrence of WoS in MS patients treated with natalizumab.

Methods: We performed longitudinal measurements of sNfL and sGFAP in NEXT-MS trial participants who completed a questionnaire about WoS.

Results: A total of 364 participants were included. In total, 55.5% presented with WoS and 44.5% without WoS during natalizumab treatment. Longitudinal analyses showed no association between sNfL and sGFAP levels and WoS at any timepoint. Biomarker levels at baseline did not predict first-time WoS occurrence.

Conclusion: Acute and chronic neuronal and axonal damage are most likely not the underlying cause of WoS.

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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
期刊最新文献
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