肝病中的二磷酸尿苷葡萄糖醛酸转移酶 1A1：当前研究与未来方向。

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY World Journal of Gastroenterology Pub Date : 2024-10-21 DOI:10.3748/wjg.v30.i39.4305

Seok-Chan Park, Yu Ji Kim, Jong-Won Kim

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引用次数: 0

摘要

这封致编辑的信涉及题为《二磷酸尿苷葡萄糖醛酸基转移酶1A1可预防肝损伤的进展》的手稿。肝损伤期间二磷酸尿苷葡萄糖醛酸基转移酶1A1水平的升高可通过减少内质网应激、氧化应激和脂质代谢失调，阻碍肝细胞凋亡和坏死，从而减轻损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting uridine diphosphate glucuronosyltransferase 1A1 in liver disease: Current research and future directions.

The current letter to the editor pertains to the manuscript entitled 'Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury'. Increased levels of uridine diphosphate glucuronosyltransferase 1A1 during liver injury could mitigate damage by reducing endoplasmic reticulum stress, oxidative stress, and dysregulated lipid metabolism, impeding hepatocyte apoptosis and necroptosis.

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来源期刊

World Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

7.80

自引率

4.70%

发文量

464

审稿时长

2.4 months

期刊介绍： The primary aims of the WJG are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in gastroenterology and hepatology.