治疗肝细胞癌的钇-90放射栓塞治疗策略。

IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING World journal of radiology Pub Date : 2024-10-28 DOI:10.4329/wjr.v16.i10.512
Kelly Hao, Andrew J Paik, Lauren H Han, Mina S Makary
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引用次数: 0

摘要

肝细胞癌(HCC)是全球癌症相关死亡的第三大主要原因,对全球健康构成重大挑战。本文对使用钇-90(Y90)的经动脉放射栓塞术(TARE)进行了介绍和全面评述,这是一种广泛应用于不适合手术治疗的 HCC 患者的经导管手术。TARE是将放射性微球靶向送入肝脏肿瘤,为治疗不同阶段的HCC提供了一种很有前景的治疗方案。通过评估 Y90 TARE 在 HCC 早期、中期和晚期的疗效,本综述旨在全面了解其疗效和安全性。此外,本文还强调了未来的研究方向,重点关注与全身疗法和免疫疗法以及个性化疗法相结合的潜力。对这些创新方法的探索旨在改善治疗效果、减少不良反应并为 HCC 患者提供新的治疗机会。综述强调了正在进行的研究和临床试验对进一步优化 TARE 并将其纳入 HCC 综合治疗范例的重要性。
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Yttrium-90 radioembolization treatment strategies for management of hepatocellular carcinoma.

As the third leading cause of cancer-related deaths worldwide, hepatocellular carcinoma (HCC) represents a significant global health challenge. This paper provides an introduction and comprehensive review of transarterial radioembolization (TARE) with Yttrium-90 (Y90), a widely performed transcatheter procedure for HCC patients who are not suitable candidates for surgery. TARE involves the targeted delivery of radioactive microspheres to liver tumors, offering a promising treatment option for managing HCC across various stages of the disease. By evaluating Y90 TARE outcomes across early, intermediate, and advanced stages of HCC, the review aims to present a thorough understanding of its efficacy and safety. Additionally, this paper highlights future research directions focusing on the potential of combination therapies with systemic and immunotherapies, as well as personalized treatments. The exploration of these innovative approaches aims to improve treatment outcomes, reduce adverse events, and provide new therapeutic opportunities for HCC patients. The review underscores the importance of ongoing research and clinical trials to optimize TARE further and integrate it into comprehensive HCC treatment paradigms.

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来源期刊
World journal of radiology
World journal of radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
自引率
8.00%
发文量
35
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