M. Frank Erasmus, Laura Spector, Fortunato Ferrara, Roberto DiNiro, Thomas J. Pohl, Katheryn Perea-Schmittle, Wei Wang, Peter M. Tessier, Crystal Richardson, Laure Turner, Sumit Kumar, Daniel Bedinger, Pietro Sormanni, Monica L. Fernández-Quintero, Andrew B. Ward, Johannes R. Loeffler, Olivia M. Swanson, Charlotte M. Deane, Matthew I. J. Raybould, Andreas Evers, Carolin Sellmann, Sharrol Bachas, Jeff Ruffolo, Horacio G. Nastri, Karthik Ramesh, Jesper Sørensen, Rebecca Croasdale-Wood, Oliver Hijano, Camila Leal-Lopes, Melody Shahsavarian, Yu Qiu, Paolo Marcatili, Erik Vernet, Rahmad Akbar, Simon Friedensohn, Rick Wagner, Vinodh babu Kurella, Shipra Malhotra, Satyendra Kumar, Patrick Kidger, Juan C. Almagro, Eric Furfine, Marty Stanton, Christilyn P. Graff, Santiago David Villalba, Florian Tomszak, Andre A. R. Teixeira, Elizabeth Hopkins, Molly Dovner, Sara D’Angelo, Andrew R. M. Bradbury
{"title":"AIntibody:经实验验证的硅学抗体发现设计挑战","authors":"M. Frank Erasmus, Laura Spector, Fortunato Ferrara, Roberto DiNiro, Thomas J. Pohl, Katheryn Perea-Schmittle, Wei Wang, Peter M. Tessier, Crystal Richardson, Laure Turner, Sumit Kumar, Daniel Bedinger, Pietro Sormanni, Monica L. Fernández-Quintero, Andrew B. Ward, Johannes R. Loeffler, Olivia M. Swanson, Charlotte M. Deane, Matthew I. J. Raybould, Andreas Evers, Carolin Sellmann, Sharrol Bachas, Jeff Ruffolo, Horacio G. Nastri, Karthik Ramesh, Jesper Sørensen, Rebecca Croasdale-Wood, Oliver Hijano, Camila Leal-Lopes, Melody Shahsavarian, Yu Qiu, Paolo Marcatili, Erik Vernet, Rahmad Akbar, Simon Friedensohn, Rick Wagner, Vinodh babu Kurella, Shipra Malhotra, Satyendra Kumar, Patrick Kidger, Juan C. Almagro, Eric Furfine, Marty Stanton, Christilyn P. Graff, Santiago David Villalba, Florian Tomszak, Andre A. R. Teixeira, Elizabeth Hopkins, Molly Dovner, Sara D’Angelo, Andrew R. M. Bradbury","doi":"10.1038/s41587-024-02469-9","DOIUrl":null,"url":null,"abstract":"<p>Science is frequently subject to the Gartner hype cycle<sup>1</sup>: emergent technologies spark intense initial enthusiasm with the recruitment of dedicated scientists. As limitations are recognized, disillusionment often sets in; some scientists turn away, disappointed in the inability of the new technology to deliver on initial promise, while others persevere and further develop the technology. Although the value (or not) of a new technology usually becomes clear with time, appropriate benchmarks can be invaluable in highlighting strengths and areas for improvement, substantially speeding up technology maturation. A particular challenge in computational engineering and artificial intelligence (AI)/machine learning (ML) is that benchmarks and best practices are uncommon, so it is particularly hard for non-experts to assess the impact and performance of these methods. Although multiple papers have highlighted best practices and evaluation guidelines<sup>2,3,4</sup>, the true test for such methods is ultimately prospective performance, which requires experimental testing.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":33.1000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"AIntibody: an experimentally validated in silico antibody discovery design challenge\",\"authors\":\"M. Frank Erasmus, Laura Spector, Fortunato Ferrara, Roberto DiNiro, Thomas J. Pohl, Katheryn Perea-Schmittle, Wei Wang, Peter M. Tessier, Crystal Richardson, Laure Turner, Sumit Kumar, Daniel Bedinger, Pietro Sormanni, Monica L. Fernández-Quintero, Andrew B. Ward, Johannes R. Loeffler, Olivia M. Swanson, Charlotte M. Deane, Matthew I. J. Raybould, Andreas Evers, Carolin Sellmann, Sharrol Bachas, Jeff Ruffolo, Horacio G. Nastri, Karthik Ramesh, Jesper Sørensen, Rebecca Croasdale-Wood, Oliver Hijano, Camila Leal-Lopes, Melody Shahsavarian, Yu Qiu, Paolo Marcatili, Erik Vernet, Rahmad Akbar, Simon Friedensohn, Rick Wagner, Vinodh babu Kurella, Shipra Malhotra, Satyendra Kumar, Patrick Kidger, Juan C. Almagro, Eric Furfine, Marty Stanton, Christilyn P. Graff, Santiago David Villalba, Florian Tomszak, Andre A. R. Teixeira, Elizabeth Hopkins, Molly Dovner, Sara D’Angelo, Andrew R. M. Bradbury\",\"doi\":\"10.1038/s41587-024-02469-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Science is frequently subject to the Gartner hype cycle<sup>1</sup>: emergent technologies spark intense initial enthusiasm with the recruitment of dedicated scientists. As limitations are recognized, disillusionment often sets in; some scientists turn away, disappointed in the inability of the new technology to deliver on initial promise, while others persevere and further develop the technology. Although the value (or not) of a new technology usually becomes clear with time, appropriate benchmarks can be invaluable in highlighting strengths and areas for improvement, substantially speeding up technology maturation. A particular challenge in computational engineering and artificial intelligence (AI)/machine learning (ML) is that benchmarks and best practices are uncommon, so it is particularly hard for non-experts to assess the impact and performance of these methods. 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AIntibody: an experimentally validated in silico antibody discovery design challenge
Science is frequently subject to the Gartner hype cycle1: emergent technologies spark intense initial enthusiasm with the recruitment of dedicated scientists. As limitations are recognized, disillusionment often sets in; some scientists turn away, disappointed in the inability of the new technology to deliver on initial promise, while others persevere and further develop the technology. Although the value (or not) of a new technology usually becomes clear with time, appropriate benchmarks can be invaluable in highlighting strengths and areas for improvement, substantially speeding up technology maturation. A particular challenge in computational engineering and artificial intelligence (AI)/machine learning (ML) is that benchmarks and best practices are uncommon, so it is particularly hard for non-experts to assess the impact and performance of these methods. Although multiple papers have highlighted best practices and evaluation guidelines2,3,4, the true test for such methods is ultimately prospective performance, which requires experimental testing.
期刊介绍:
Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research.
The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field.
Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology.
In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.