Yue Wei , Guishun Bai , Jiamin Wu , Yi Hua , Tao Zhang , Congyong Yue , Hong Wang , Xiaoze Bao
{"title":"3- 羟基喹啉-2(1H)-酮与异靛红和吡唑-4,5-二酮衍生酮亚胺的对映选择性加成","authors":"Yue Wei , Guishun Bai , Jiamin Wu , Yi Hua , Tao Zhang , Congyong Yue , Hong Wang , Xiaoze Bao","doi":"10.1039/d4qo01895h","DOIUrl":null,"url":null,"abstract":"<div><div>The enantioselective reactivity of 3-hydroxyquinolin-2(1<em>H</em>)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural product scaffolds in high yields with excellent enantioselectivities. Gram-scale synthesis and synthetic transformations further disclosed the potential of the current process.</div></div>","PeriodicalId":94379,"journal":{"name":"Organic chemistry frontiers : an international journal of organic chemistry","volume":"12 2","pages":"Pages 497-502"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enantioselective addition of 3-hydroxyquinolin-2(1H)-one to isatin and pyrazole-4,5-dione derived ketimines†\",\"authors\":\"Yue Wei , Guishun Bai , Jiamin Wu , Yi Hua , Tao Zhang , Congyong Yue , Hong Wang , Xiaoze Bao\",\"doi\":\"10.1039/d4qo01895h\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The enantioselective reactivity of 3-hydroxyquinolin-2(1<em>H</em>)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural product scaffolds in high yields with excellent enantioselectivities. Gram-scale synthesis and synthetic transformations further disclosed the potential of the current process.</div></div>\",\"PeriodicalId\":94379,\"journal\":{\"name\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"volume\":\"12 2\",\"pages\":\"Pages 497-502\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S2052412924007952\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic chemistry frontiers : an international journal of organic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2052412924007952","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/5 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Enantioselective addition of 3-hydroxyquinolin-2(1H)-one to isatin and pyrazole-4,5-dione derived ketimines†
The enantioselective reactivity of 3-hydroxyquinolin-2(1H)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural product scaffolds in high yields with excellent enantioselectivities. Gram-scale synthesis and synthetic transformations further disclosed the potential of the current process.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
