苯并[f]喹唑啉-1,3(2H,4H)-二酮的合成。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC Beilstein Journal of Organic Chemistry Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.228

Ruben Manuel Figueira de Abreu, Peter Ehlers, Peter Langer

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引用次数: 0

摘要

我们报告了多环尿嘧啶衍生物的合成。该方法基于钯催化的 Sonogashira-Hagihara 和 Suzuki-Miyaura 交叉偶联反应，然后是 Brønsted 酸介导的环异构化反应。所开发的方法可容忍各种官能团，并可导致最终产物的中等至定量产率。通过紫外可见光谱和荧光光谱研究了不同官能团对光学性质的影响。

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Synthesis of benzo[f]quinazoline-1,3(2H,4H)-diones.

We report the synthesis of polycyclic uracil derivatives. The method is based on palladium-catalysed Sonogashira-Hagihara and Suzuki-Miyaura cross-coupling reactions followed by Brønsted acid-mediated cycloisomerisation. The developed methodology tolerates various functional groups and leads to moderate up to quantitative yields of the final products. The impact of different functional groups on the optical properties was studied by UV-vis and fluorescence spectroscopy.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.