2 型糖尿病和脂肪肝患者出现血管并发症的风险增加。

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM BMC Endocrine Disorders Pub Date : 2024-11-05 DOI:10.1186/s12902-024-01766-3
Weixia Sun, Dechen Liu, Ting Yang, Ziwei Zhou, Dan Li, Zhuoxiao Zhao, Xuan Zhang, Liyun Wang, Ling Li
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引用次数: 0

摘要

背景:2型糖尿病(T2DM)患者中脂肪性肝病(SLD)的发病率超过50%。本研究旨在调查中国 T2DM 患者脂肪肝和肝纤维化的临床特征:研究纳入了 2021 年至 2023 年的住院患者。脂肪肝指数(FLI)和肝纤维化-4(FIB-4)分别用于评估肝脏脂肪变性和肝纤维化。统计分析由 SPSS v25 和 GraphPad Prism v8.0.1 完成:在1466名参与者中,T2DM-SLD组约三分之一的患者被诊断为肝纤维化(LF),50岁以上的患者占85.9%。SLD患者的体重指数(BMI)、血压、肝酶、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、C肽、总胆固醇(TC)和甘油三酯(TG)水平均较高:肝脏脂肪变性和纤维化在 T2DM 患者中很常见。肝纤维化与许多糖尿病大血管和微血管并发症有关。
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Increased risk of vascular complications in patients with type 2 diabetes and fatty liver disease.

Background: The prevalence of steatotic liver disease (SLD) in patients with type 2 diabetes (T2DM) exceeds 50%. This study aimed to investigate the clinical characteristics of SLD and liver fibrosis in Chinese patients with T2DM.

Methods: Inpatients from 2021 to 2023 were included in the study. Fatty liver index (FLI) and fibrosis-4 (FIB-4) were calculated to assess hepatic steatosis and fibrosis respectively. Statistical analysis was completed by SPSS v25 and GraphPad Prism v8.0.1.

Results: Of the 1466 participants, about one-third of the patients in T2DM-SLD group were diagnosed with liver fibrosis (LF), and the percentage of patients over 50 years old was 85.9%. Patients with SLD had higher levels of BMI, blood pressure, liver enzymes, fasting blood glucose (FBG), HbA1c, C-peptide, total cholesterol (TC) and triglyceride (TG) (P<0.05 for all). Patients with liver fibrosis had lower TC, TG, hemoglobin (Hb), erythrocyte count (RBC), leukocyte count (WBC) and platelet (PLT) levels (P<0.05 for all). Compared with simple T2DM and SLD-NLF (non-liver fibrosis) groups, for patients over 50 years old, the prevalence of coronary heart disease, stroke, tumor, and diabetic nephropathy was higher in patients with liver fibrosis. Liver fibrosis might be the risk factor of arterial stiffness, stroke, coronary heart disease and numbness based on multivariable logistic regression analysis.

Conclusion: Hepatic steatosis and fibrosis were common in patients with T2DM. Liver fibrosis was relevant to many macrovascular and microvascular diabetic complications.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
期刊最新文献
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