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引用次数: 0
摘要
开发了一种以钼为介质的硝基烯烃与醇的还原性原烷基化反应，用于合成原烷基化苯胺。使用 Mo(CO)6 作为还原剂和催化剂，从硝基烯烃和醇中制备出了一系列原烷基取代的苯胺。初步的机理研究表明，硝基烯烃在 H2O 的存在下被 Mo(CO)6 还原成苯胺，而氧化 Mo 物催化了该反应的烷基化部分。
Molybdenum-Mediated Reductive ortho-Alkylation of Nitroarenes with Alcohols.
A molybdenum-mediated reductive ortho-alkylation of nitroarenes with alcohols for the synthesis of ortho-alkylated anilines has been developed. Using Mo(CO)6 as both the reductant and the catalyst, a range of ortho-alkyl-substituted anilines were prepared from nitroarenes and alcohols. Preliminary mechanistic studies indicate that nitroarenes were reduced by Mo(CO)6 to aniline in the presence of H2O, while an oxidized Mo species catalyzed the alkylation portion of this reaction.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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