p120-catenin 在生理和疾病中的功能。

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Frontiers in Molecular Biosciences Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.3389/fmolb.2024.1486576

Xin Jin, Ting Lin, Yunjuan Wang, Xiaoqian Li, Yanhong Yang

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引用次数: 0

摘要

p120-catenin（p120）在调节粘连接头处的细胞-细胞粘附中发挥着重要作用，它与 E-粘连蛋白的并膜结构域（JMD）核心区相互作用，并调节细胞表面粘连蛋白的稳定性。以往的研究表明，p120 在细胞-细胞粘附、肿瘤进展和炎症中具有重要功能。在这篇综述中，我们将讨论 p120 在生理过程和疾病中的最新进展，并重点关注 p120 在调控癌症和炎症中的功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Functions of p120-catenin in physiology and diseases.

p120-catenin (p120) plays a vital role in regulating cell-cell adhesion at adherens junctions, interacting with the juxtamembrane domain (JMD) core region of E-cadherin and regulates the stability of cadherin at the cell surface. Previous studies have shown significant functions of p120 in cell-cell adhesion, tumor progression and inflammation. In this review, we will discuss recent progress of p120 in physiological processes and diseases, and focus on the functions of p120 in the regulation of cancer and inflammation.

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.