非糖尿病年轻女性群体中亚临床甲状腺机能减退的患病率及其对糖尿病和心脏代谢风险的影响

IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrinology and Metabolism Pub Date : 2024-11-05 DOI:10.3803/EnM.2024.2015
Nawoda Hewage, Udaya Wijesekara, Rasika Perera
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引用次数: 0

摘要

背景:我们评估了亚临床甲状腺功能减退症(SCH)对未患糖尿病的育龄妇女的胰岛素抵抗(IR)、心脏代谢风险和肥胖的影响:这项横断面调查包括来自斯里兰卡农村和郊区的 282 名 18 至 35 岁女性。记录了人体测量和生化参数,包括红外和血脂/甲状腺概况。比较了对照组(体重正常)和病例(超重/肥胖)中 SCH 和甲状腺功能正常(EU)之间的数据:结果:SCH、EU、IR 和代谢综合征(MetS)的总发病率分别为 40.42%、59.57%、73.40% 和 24.46%。对照组和病例中均包括 SCH 患者;总体而言,168 人(59.57%)患有 EU,114 人(40.42%)表现出 SCH。在两个体重组中,IR与SCH均有明显相关性(对照组为P2(95% 置信区间[CI],0.45 至 3.87),病例组为>6(95% 置信区间[CI],3.52 至 8.41)。同样,MetS的OR值在对照组中>1(95% CI,0.38至4.16),在病例中>11(95% CI,8.73至15.01)。在SCH组中,血脂异常和高甘油三酯血症的发病率明显更高(结论:必须对年轻女性中的 SCH 进行识别和管理,以帮助预防糖尿病和心脏代谢疾病。VAI 可帮助精确检测 SCH 和心血管疾病。
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Prevalence of Subclinical Hypothyroidism in a Non-Diabetic Young Female Population and Its Impact on Diabetes and Cardiometabolic Risk.

Background: We evaluated the influence of subclinical hypothyroidism (SCH) on insulin resistance (IR), cardiometabolic risk, and obesity in childbearing-age women without diabetes.

Methods: This cross-sectional investigation included 282 women, aged 18 to 35 years, from rural and suburban Sri Lanka. Anthropometric and biochemical parameters, including IR and lipid/thyroid profiles, were recorded. Data were compared between SCH and euthyroidism (EU) for controls (normal weight) and cases (overweight/obese).

Results: The overall rates of SCH, EU, IR, and metabolic syndrome (MetS) were 40.42%, 59.57%, 73.40%, and 24.46%, respectively. Both controls and cases included individuals with SCH; overall, 168 participants (59.57%) had EU, while 114 (40.42%) exhibited SCH. IR was significantly associated with SCH in both weight groups (P<0.05). Among those with SCH, the odds ratios (ORs) for IR were >2 (95% confidence interval [CI], 0.45 to 3.87) in controls and >6 (95% CI, 3.52 to 8.41) in cases. Similarly, the ORs for MetS were >1 (95% CI, 0.38 to 4.16) in controls and >11 (95% CI, 8.73 to 15.01) in cases. Dyslipidemia and hypertriglyceridemia were significantly more prevalent in the SCH group (P<0.05). Women with SCH exhibited higher mean values for all obesity indices compared to their EU counterparts, surpassing normal thresholds (P<0.05). Among obesity measures, visceral adiposity index (VAI) demonstrated the highest area under the curve and sensitivity for assessing SCH and cardiovascular disease (CVD) risk.

Conclusion: SCH must be identified and managed in young women to help prevent diabetes and cardiometabolic disorders. VAI may aid in precisely detecting SCH and CVD.

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来源期刊
Endocrinology and Metabolism
Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.60
自引率
5.90%
发文量
145
审稿时长
24 weeks
期刊介绍: The aim of this journal is to set high standards of medical care by providing a forum for discussion for basic, clinical, and translational researchers and clinicians on new findings in the fields of endocrinology and metabolism. Endocrinology and Metabolism reports new findings and developments in all aspects of endocrinology and metabolism. The topics covered by this journal include bone and mineral metabolism, cytokines, developmental endocrinology, diagnostic endocrinology, endocrine research, dyslipidemia, endocrine regulation, genetic endocrinology, growth factors, hormone receptors, hormone action and regulation, management of endocrine diseases, clinical trials, epidemiology, molecular endocrinology, neuroendocrinology, neuropeptides, neurotransmitters, obesity, pediatric endocrinology, reproductive endocrinology, signal transduction, the anatomy and physiology of endocrine organs (i.e., the pituitary, thyroid, parathyroid, and adrenal glands, and the gonads), and endocrine diseases (diabetes, nutrition, osteoporosis, etc.).
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