Yaqin Tang, Qiyu Li, Ziwei Zhou, Huayang Bai, Nianting Xiao, Jing Xie, Chong Li
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引用次数: 0
摘要
气体疗法已成为治疗癌症的一种前景广阔的方法，氮氧化物、H2S 和 CO 等气体显示出积极的效果。其中，氮氧化物被认为是一种关键的气体分子，在阻止癌症进展方面潜力巨大。然而，由于 NO 的高反应性和短半衰期，将 NO 直接输送到肿瘤是加强癌症治疗的关键。氮氧化物驱动的纳米药物（NONs）已被开发出来，可有效地向肿瘤输送氮氧化物供体，近年来取得了巨大进展。本综述概述了基于 NO 的癌症纳米疗法的最新进展。它讨论了当前研究中使用的氮氧化物供体类型、氮氧化物治疗癌症的作用机制以及纳米疗法中氮氧化物供体的不同递送系统。报告还探讨了将氮氧化物供体与其他疗法相结合以增强癌症疗法的潜力。最后，它探讨了在临床环境中使用氮氧化物治疗癌症的未来前景和挑战。
Nitric oxide-based multi-synergistic nanomedicine: an emerging therapeutic for anticancer.
Gas therapy has emerged as a promising approach for treating cancer, with gases like NO, H2S, and CO showing positive effects. Among these, NO is considered a key gas molecule with significant potential in stopping cancer progression. However, due to its high reactivity and short half-life, delivering NO directly to tumors is crucial for enhancing cancer treatment. NO-driven nanomedicines (NONs) have been developed to effectively deliver NO donors to tumors, showing great progress in recent years. This review provides an overview of the latest advancements in NO-based cancer nanotherapeutics. It discusses the types of NO donors used in current research, the mechanisms of action behind NO therapy for cancer, and the different delivery systems for NO donors in nanotherapeutics. It also explores the potential of combining NO donors with other treatments for enhanced cancer therapy. Finally, it examines the future prospects and challenges of using NONs in clinical settings for cancer treatment.
期刊介绍：
Journal of Nanobiotechnology is an open access peer-reviewed journal communicating scientific and technological advances in the fields of medicine and biology, with an emphasis in their interface with nanoscale sciences. The journal provides biomedical scientists and the international biotechnology business community with the latest developments in the growing field of Nanobiotechnology.
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