光诱导 EDA 复合物引发的氟烷基异喹啉酮类化合物的合成。

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemistry - A European Journal Pub Date : 2024-11-06 DOI:10.1002/chem.202403286

Lei Huang, Chaodong Wang, Zhi Chen, Qianxi Jin, Shengjie Song, Jiadi Zhou, Jianjun Li

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引用次数: 0

摘要

本研究开发了一种可见光诱导的自由基串联二氟烷基化/环化反应，以构建含有甲基丙烯酰基苯甲酰胺的含 CF2 的异喹啉酮骨架。在室温条件下，广泛的底物范围与无金属、无氧化剂和无光催化剂条件兼容，产率良好至极佳。机理分析表明，这种转化是由光诱导电子供体-受体（EDA）复合物的形成启动的。

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Photoinduced EDA Complex-Initiated Synthesis of Fluoroalkylated Isoquinolinonediones.

A visible-light-induced radical tandem difluoroalkylation/cyclization to construct CF₂-containing isoquinolinonedione skeletons with methacryloyl benzamides is developed. Broad substrate scopes are compatible with metal-, oxidant- and photocatalyst-free conditions under room temperature in good-to-excellent yields. Mechanistic analysis revealed that the transformation is initiated by photoinduced electron donor-acceptor (EDA) complexes formation.

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.