壳聚糖基纳米制剂:针对不同病症的临床前研究、治疗学进展和临床试验前景。

IF 3.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY AAPS PharmSciTech Pub Date : 2024-11-05 DOI:10.1208/s12249-024-02948-x
Seema Yadav, Abhishek Singh, Narahari N. Palei, Prateek Pathak, Amita Verma, Jagat Pal Yadav
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引用次数: 0

摘要

壳聚糖是一种生物相容性和可生物降解的聚合物,在开发用于靶向给药和治疗应用的纳米制剂方面引起了极大的兴趣。壳聚糖的多功能性在于其可修饰的官能团,可根据不同的应用进行定制。壳聚糖及其衍生物制成的纳米颗粒通常具有正表面电荷和粘液粘附特性,使其能够粘附在带负电荷的生物膜上,并逐渐释放治疗药物。这篇综合性综述探讨了壳聚糖基纳米载体的多种作用,从临床前研究到治疗应用和临床试验,涉及多种疾病,包括神经系统疾病、心血管疾病、癌症、伤口愈合、胃肠道疾病和肺部疾病。探讨从临床前研究概述开始,强调基于壳聚糖的纳米制剂在优化药物输送、改善治疗效果和减轻各类疾病的不良反应方面的潜力。基于壳聚糖的纳米制剂在治疗学应用方面取得的进展突显了其对各种疾病的适应性。随着这些纳米制剂逐步应用于临床,本综述还探讨了与其开发相关的监管挑战,并提出了潜在的解决方案。
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Chitosan-Based Nanoformulations: Preclinical Investigations, Theranostic Advancements, and Clinical Trial Prospects for Targeting Diverse Pathologies

Chitosan, a biocompatible and biodegradable polymer, has attracted significant interest in the development of nanoformulations for targeted drug delivery and therapeutic applications. The versatility of chitosan lies in its modifiable functional groups, which can be tailored to diverse applications. Nanoparticles derived from chitosan and its derivatives typically exhibit a positive surface charge and mucoadhesive properties, enabling them to adhere to negatively charged biological membranes and gradually release therapeutic agents. This comprehensive review investigates the manifold roles of chitosan-based nanocarriers, ranging from preclinical research to theranostic applications and clinical trials, across a spectrum of diseases, including neurological disorders, cardiovascular diseases, cancer, wound healing, gastrointestinal disorders, and pulmonary diseases. The exploration starts with an overview of preclinical studies, emphasizing the potential of chitosan-based nanoformulations in optimizing drug delivery, improving therapeutic outcomes, and mitigating adverse effects in various disease categories. Advancements in theranostic applications of chitosan-based nanoformulations highlight their adaptability to diverse diseases. As these nanoformulations progress toward clinical translation, this review also addresses the regulatory challenges associated with their development and proposes potential solutions.

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来源期刊
AAPS PharmSciTech
AAPS PharmSciTech 医学-药学
CiteScore
6.80
自引率
3.00%
发文量
264
审稿时长
2.4 months
期刊介绍: AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.
期刊最新文献
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