Mujtaba Khalil, Selamawit Woldesenbet, Muhammad Musaab Munir, Zayed Rashid, Muhammad Muntazir Mehdi Khan, Abdullah Altaf, Vennila Padmanaban, Mary Dillhoff, Mark Arnold, Timothy M. Pawlik
{"title":"手术阿片类药物处方与未服用阿片类药物家庭开始服用阿片类药物的风险。","authors":"Mujtaba Khalil, Selamawit Woldesenbet, Muhammad Musaab Munir, Zayed Rashid, Muhammad Muntazir Mehdi Khan, Abdullah Altaf, Vennila Padmanaban, Mary Dillhoff, Mark Arnold, Timothy M. Pawlik","doi":"10.1016/j.amjsurg.2024.116029","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>We sought to investigate the association between surgical opioid prescriptions and the risk of opioid initiation among opioid-naive spouses.</div></div><div><h3>Methods</h3><div>Patients who underwent surgery for breast or gastrointestinal cancer were identified from the IBM Marketscan database. Multivariable regression analysis was performed to examine the association between surgical opioid prescription and opioid initiation among opioid-naïve patient spouses.</div></div><div><h3>Results</h3><div>Among the 9365 individuals included in the analytic cohort, 77.9 % (n = 7300) filled a perioperative opioid prescription. Of note, spouses of patients who received a surgical opioid prescription (6.7 % vs. 4.5 %; p < 0.001) were more likely to begin using opioids. On multivariable analysis, surgical opioid prescription was associated with 61 % (1.61, 95%CI 1.28–2.03) higher odds of opioid initiation among opioid-naïve spouses.</div></div><div><h3>Conclusion</h3><div>Surgical opioid prescriptions are associated with an increased risk of opioid initiation among opioid-naive spouses. These findings underscore the importance of counseling on safe opioid use, storage, and disposal for the family.</div></div>","PeriodicalId":7771,"journal":{"name":"American journal of surgery","volume":"241 ","pages":"Article 116029"},"PeriodicalIF":2.7000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Surgical opioid prescription and the risk of opioid initiation among opioid-naive households\",\"authors\":\"Mujtaba Khalil, Selamawit Woldesenbet, Muhammad Musaab Munir, Zayed Rashid, Muhammad Muntazir Mehdi Khan, Abdullah Altaf, Vennila Padmanaban, Mary Dillhoff, Mark Arnold, Timothy M. Pawlik\",\"doi\":\"10.1016/j.amjsurg.2024.116029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>We sought to investigate the association between surgical opioid prescriptions and the risk of opioid initiation among opioid-naive spouses.</div></div><div><h3>Methods</h3><div>Patients who underwent surgery for breast or gastrointestinal cancer were identified from the IBM Marketscan database. Multivariable regression analysis was performed to examine the association between surgical opioid prescription and opioid initiation among opioid-naïve patient spouses.</div></div><div><h3>Results</h3><div>Among the 9365 individuals included in the analytic cohort, 77.9 % (n = 7300) filled a perioperative opioid prescription. Of note, spouses of patients who received a surgical opioid prescription (6.7 % vs. 4.5 %; p < 0.001) were more likely to begin using opioids. On multivariable analysis, surgical opioid prescription was associated with 61 % (1.61, 95%CI 1.28–2.03) higher odds of opioid initiation among opioid-naïve spouses.</div></div><div><h3>Conclusion</h3><div>Surgical opioid prescriptions are associated with an increased risk of opioid initiation among opioid-naive spouses. These findings underscore the importance of counseling on safe opioid use, storage, and disposal for the family.</div></div>\",\"PeriodicalId\":7771,\"journal\":{\"name\":\"American journal of surgery\",\"volume\":\"241 \",\"pages\":\"Article 116029\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0002961024005816\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002961024005816","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
Surgical opioid prescription and the risk of opioid initiation among opioid-naive households
Background
We sought to investigate the association between surgical opioid prescriptions and the risk of opioid initiation among opioid-naive spouses.
Methods
Patients who underwent surgery for breast or gastrointestinal cancer were identified from the IBM Marketscan database. Multivariable regression analysis was performed to examine the association between surgical opioid prescription and opioid initiation among opioid-naïve patient spouses.
Results
Among the 9365 individuals included in the analytic cohort, 77.9 % (n = 7300) filled a perioperative opioid prescription. Of note, spouses of patients who received a surgical opioid prescription (6.7 % vs. 4.5 %; p < 0.001) were more likely to begin using opioids. On multivariable analysis, surgical opioid prescription was associated with 61 % (1.61, 95%CI 1.28–2.03) higher odds of opioid initiation among opioid-naïve spouses.
Conclusion
Surgical opioid prescriptions are associated with an increased risk of opioid initiation among opioid-naive spouses. These findings underscore the importance of counseling on safe opioid use, storage, and disposal for the family.
期刊介绍：
The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.
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