白癜风患者并存自身免疫性疾病和自身炎症性疾病的患病率:埃及的一项调查研究。

IF 2.1 Q3 RHEUMATOLOGY BMC Rheumatology Pub Date : 2024-11-06 DOI:10.1186/s41927-024-00427-1
Samar Tharwat, Fatma Hamdy, Sara Hamdy, Mohammed Kamal Nassar
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引用次数: 0

摘要

背景:白癜风的确切病因尚不清楚。遗传因素、黑色素细胞自毁、自身免疫过程和氧化应激都可能导致白癜风的发病:本研究旨在了解埃及白癜风患者同时患有自身免疫性疾病和自身炎症性疾病(AIIDs)的频率,并确定相关的风险因素:要求埃及儿童和成人白癜风患者及其家长回答一项网络调查。该调查由围绕人口统计学、临床和治疗数据的多个问题组成。对所有患者的白癜风疾病活动性(VIDA)评分进行了评估。此外,还询问了患者是否同时患有AIIDs:共有 294 名参与者,大部分为女性(54.8%),年龄中位数为 35 岁,病程中位数为 9 年。近 27% 的人至少患有一种 AIID。最常见的相关 AIID 是自身免疫性甲状腺疾病(47 名患者,16%),其次是斑秃(14 名患者,4.8%),然后是银屑病和类风湿性关节炎(11 名患者,3.7%)。单变量回归分析表明,年龄(OR 1.02,P = 0.036)、女性性别(OR 2.2,P = 0.004)、病程(OR 1.04,P 结论:AIIDs 是一种常见的皮肤病:AIID在白癜风患者中很普遍。年龄、女性性别和 AIIDs 家族史是白癜风患者出现 AIIDs 的主要预测因素。
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Prevalence of co-existing autoimmune and autoinflammatory diseases in vitiligo: a survey-based study from Egypt.

Background: The exact cause of vitiligo is still unknown. Genetic factors, self-destruction of melanocytes, the autoimmune process, and oxidative stress all can contribute to the pathogenesis of vitiligo.

Objectives: The aim of this study was to figure out the frequency of coexisting autoimmune and autoinflammatory diseases (AIIDs) in Egyptian patients with vitiligo and identify the associated risk factors.

Materials and methods: Egyptian children and adults with vitiligo and their parents were asked to answer a web-based survey. The survey consisted of multiple questions centered around demographic, clinical, and therapeutic data. The vitiligo disease activity (VIDA) score was evaluated for all the patients. Patients were also asked about the presence of co-existing AIIDs.

Results: There was a total of 294 participants, mostly females (54.8%), with a median age of 35 years and a median disease duration of 9 years. Nearly 27% had at least one AIID. The most common associated AIIDs were autoimmune thyroid disease (47 patients, 16%), followed by alopecia areata (14 patients,4.8%), then psoriasis and rheumatoid arthritis (11 patients, 3.7%). Univariate regression analysis revealed that age (OR 1.02, P = 0.036), female gender (OR 2.2, P = 0.004), disease duration (OR 1.04, P < 0.001), affected body surface area (OR 1.7, P = 0.048), and family history of AIIDs (OR 2.7, P < 0.001) were predictors for the presence of AIIDs in patients with vitiligo.

Conclusion: AIIDs are prevalent among vitiligo patients. Age, female gender, and family history of AIIDs are the main predictors of the presence of AIIDs in vitiligo patients.

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来源期刊
BMC Rheumatology
BMC Rheumatology Medicine-Rheumatology
CiteScore
3.80
自引率
0.00%
发文量
73
审稿时长
15 weeks
期刊最新文献
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