鉴定茜草根中的新化合物

IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry & Biodiversity Pub Date : 2024-11-05 DOI:10.1002/cbdv.202401792
Qing Li, Min-Min Gu, Yu Zhang, Jin Wang, Yun-Yun Su, Hao-Lin Yu, Chen-Sen Xu, Zhi-Xin Liao
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引用次数: 0

摘要

西藏茜草(Rubia tibetica Hook. f)是一种传统的藏药用植物,其根部是主要的药用部分。从茜草中分离出了两种新化合物 Rubiaxylm C 和 E(1 和 3),一种新的天然化合物 Rubiaxylm D(2),以及五种已知化合物(4-8)。通过 HR-ESIMS、一维/二维核磁共振光谱数据和电子圆二色性计算,阐明了以前未曾描述过的化合物的结构。化合物 1 是一种罕见的在第 1 位被羰基取代的蒽酮。此外,还测试了所有分离化合物对 HepG2 细胞系的细胞毒性。
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Identification of New Compounds from the Roots of Rubia tibetica Hook. f.

Rubia tibetica Hook. f is a traditional Tibetan medicinal plant, with its roots serving as the primary medicinal part. Two new compounds, Rubiaxylm C and E (1 and 3), and one new natural compound, Rubiaxylm D (2) were isolated from R. tibetica, along with five known compounds (4-8). The structures of the previously undescribed compounds were elucidated by HR-ESIMS, 1D/2D NMR spectroscopic data and electronic circular dichroism calculations. Compound 1 is a rare anthrone substituted with a carbonyl group at position 1. Furthermore, all isolated compounds were tested for their cytotoxicity against HepG2 cell lines.

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来源期刊
Chemistry & Biodiversity
Chemistry & Biodiversity 环境科学-化学综合
CiteScore
3.40
自引率
10.30%
发文量
475
审稿时长
2.6 months
期刊介绍: Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.
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