用于提高动物寄生虫感染治疗中艾普罗米星经皮 c 效率的无穿透增强剂混合胶束

IF 6.6 2区 医学 Q1 NANOSCIENCE & NANOTECHNOLOGY International Journal of Nanomedicine Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S476164
Yujuan Mao, Tianjiao Hao, Hongxiu Zhang, Xiaofei Gu, Jing Wang, Feifei Shi, Xiaolan Chen, Liuna Guo, Jie Gao, Yan Shen, JinLin Zhang, Shenglan Yu
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引用次数: 0

摘要

介绍:埃普瑞诺米星有望防治寄生虫感染。本研究开发了用于透皮给药的埃普瑞诺米星(EPR)混合胶束,旨在提高对内寄生虫和外寄生虫的疗效和便利性。研究人员进行了理化表征和药代动力学研究,以评估其作为寄生虫感染有效治疗方法的潜力:使用 PEG-40 氢化蓖麻油(RH-40)和壬基酚聚氧乙烯醚 40(NP-40)制备空白胶束和 EPR 混合胶束。使用芘荧光探针法测定临界胶束浓度(CMC)。对粒度、EE、DL、体外释放、渗透性和皮肤刺激性进行了评估。在雄性 Sprague-Dawley 大鼠体内进行了药代动力学研究:结果表明,EPR 混合胶束具有合适的稳定性、理化性质和安全性。此外,EPR 混合胶束的快速释放和高生物利用度也在研究中得到了验证。体内药代动力学实验表明,EPR 被混合胶束制剂包裹后,其透皮吸收和生物利用率均有所提高:结果证明,新型混合胶束安全有效,有望成为一种前景广阔的兽药纳米给药系统。
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Penetration Enhancer-Free Mixed Micelles for Improving Eprinomectin Transdermal c Efficiency in Animal Parasitic Infections Therapy.

Introduction: Eprinomectin offers promise against parasitic infections. This study develops Eprinomectin (EPR) mixed micelles for transdermal delivery, aiming to enhance efficacy and convenience against endoparasites and ectoparasites. Physicochemical characterization and pharmacokinetic studies were conducted to assess its potential as an effective treatment for parasitic infections.

Methods: Blank and EPR mixed micelles were prepared using PEG-40 Hydrogenated castor oil (RH-40) and Nonyl phenol polyoxyethylene ether 40 (NP-40). Critical micelle concentrations (CMC) determined using the pyrene fluorescence probe method. Particle size, EE, DL, in vitro release, permeation, and skin irritation were evaluated. In vivo pharmacokinetic studies were conducted in male Sprague-Dawley rats.

Results: Results show that EPR mixed micelles present suitable stability, physicochemical properties, and safety. Moreover, the rapid release and high bioavailability of EPR mixed micelles have also been verified in the study. Pharmacokinetic experiments in vivo showed that an improvement in the transdermal absorption and bioavailability of EPR after encapsulation in mixed micelles formulations.

Conclusion: The results proved that the novel mixed micelles are safe and effective and are expected to become a promising veterinary nano-delivery system.

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来源期刊
International Journal of Nanomedicine
International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY
CiteScore
14.40
自引率
3.80%
发文量
511
审稿时长
1.4 months
期刊介绍: The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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