初级纤毛协调颅神经嵴细胞的发育

IF 2.2 3区生物学 Q4 CELL BIOLOGY Differentiation Pub Date : 2024-10-30 DOI:10.1016/j.diff.2024.100818

Hiroyuki Yamaguchi, Matthew D Meyer, William B Barrell, Maryam Faisal, Rebecca Berdeaux, Karen J Liu, Yoshihiro Komatsu

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引用次数: 0

摘要

初级纤毛（以下简称 "纤毛"）是从脊椎动物细胞表面伸出的基于微管的天线状细胞器。纤毛可作为控制细胞生长和分化的细胞触角。纤毛缺失或功能障碍经常导致颅面异常，被称为颅面纤毛疾病。然而，颅面纤毛疾病的详细病理机制仍不清楚。本视角讨论了我们目前对纤毛在颅神经嵴细胞中作用的理解。我们还描述了颅神经嵴细胞中纤毛生成的潜在机制，这可能有助于揭示颅面纤毛疾病复杂的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The primary cilia: Orchestrating cranial neural crest cell development.

Primary cilia (hereafter "cilia") are microtubule-based antenna-like organelles projecting from the surface of vertebrate cells. Cilia can serve as cellular antennae controlling cell growth and differentiation. Absent or dysfunctional cilia frequently lead to craniofacial anomalies known as craniofacial ciliopathies. However, the detailed pathological mechanisms of craniofacial ciliopathies remain unclear. This perspective discusses our current understanding of the role of cilia in cranial neural crest cells. We also describe potential mechanisms of ciliogenesis in cranial neural crest cells, which may contribute to unraveling the complex pathogenesis of craniofacial ciliopathies.

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.