{"title":"在日本自我扩增的 mRNA COVID-19 疫苗推广过程中解决疫苗犹豫和误导问题。","authors":"Hayase Hakariya, Rio Ohashi","doi":"10.1093/qjmed/hcae214","DOIUrl":null,"url":null,"abstract":"<p><p>As of October 1, 2024, Japan implemented a revised COVID-19 vaccination strategy, shifting from a fully publicly funded model to one where costs are partially or fully borne by recipients. This new annual program targets individuals aged 65 and above, and those aged 60-64 at higher risk of severe illness, requiring them to cover some vaccination expenses. For others, the vaccine remains voluntary and self-funded. Notably, this program includes the world's first self-amplifying mRNA COVID-19 vaccine, zapomeran (Kostaive®, Meiji Seika Pharma Co., Ltd) approved on November 28, 2023. This vaccine's innovative self-amplifying feature has ignited debates across media platforms, with widespread public division and confusion. The new vaccine encodes replicase proteins and the spike protein antigen, allowing for reduced doses of 5 ug compared to traditional mRNA vaccines that require 30 ug. However, concerns have been raised, primarily around four misconceptions: shedding, perpetual mRNA replication, integration into human DNA, and its non-approval situation outside Japan. Despite these scientifically unfounded concerns, they have fueled vaccine hesitancy, influenced by misleading information spreading rapidly on social media. Alarmingly, biased statements from an academic university and an academic society aggravate this hesitancy. Japan's history has experienced vaccine hesitancies in human papillomavirus and diphtheria-tetanus-pertussis vaccination cases. To prevent a public health crisis, it is crucial that governmental bodies and academic groups actively counter misinformation, advocating for evidence-based understanding and encouraging vaccination among those most at risk.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":7.3000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Addressing Vaccine Hesitancy and misinformation amidst Japan's self-amplifying mRNA COVID-19 Vaccine Rollout.\",\"authors\":\"Hayase Hakariya, Rio Ohashi\",\"doi\":\"10.1093/qjmed/hcae214\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>As of October 1, 2024, Japan implemented a revised COVID-19 vaccination strategy, shifting from a fully publicly funded model to one where costs are partially or fully borne by recipients. This new annual program targets individuals aged 65 and above, and those aged 60-64 at higher risk of severe illness, requiring them to cover some vaccination expenses. For others, the vaccine remains voluntary and self-funded. Notably, this program includes the world's first self-amplifying mRNA COVID-19 vaccine, zapomeran (Kostaive®, Meiji Seika Pharma Co., Ltd) approved on November 28, 2023. This vaccine's innovative self-amplifying feature has ignited debates across media platforms, with widespread public division and confusion. The new vaccine encodes replicase proteins and the spike protein antigen, allowing for reduced doses of 5 ug compared to traditional mRNA vaccines that require 30 ug. However, concerns have been raised, primarily around four misconceptions: shedding, perpetual mRNA replication, integration into human DNA, and its non-approval situation outside Japan. Despite these scientifically unfounded concerns, they have fueled vaccine hesitancy, influenced by misleading information spreading rapidly on social media. Alarmingly, biased statements from an academic university and an academic society aggravate this hesitancy. Japan's history has experienced vaccine hesitancies in human papillomavirus and diphtheria-tetanus-pertussis vaccination cases. To prevent a public health crisis, it is crucial that governmental bodies and academic groups actively counter misinformation, advocating for evidence-based understanding and encouraging vaccination among those most at risk.</p>\",\"PeriodicalId\":20806,\"journal\":{\"name\":\"QJM: An International Journal of Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2024-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"QJM: An International Journal of Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/qjmed/hcae214\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"QJM: An International Journal of Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/qjmed/hcae214","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
As of October 1, 2024, Japan implemented a revised COVID-19 vaccination strategy, shifting from a fully publicly funded model to one where costs are partially or fully borne by recipients. This new annual program targets individuals aged 65 and above, and those aged 60-64 at higher risk of severe illness, requiring them to cover some vaccination expenses. For others, the vaccine remains voluntary and self-funded. Notably, this program includes the world's first self-amplifying mRNA COVID-19 vaccine, zapomeran (Kostaive®, Meiji Seika Pharma Co., Ltd) approved on November 28, 2023. This vaccine's innovative self-amplifying feature has ignited debates across media platforms, with widespread public division and confusion. The new vaccine encodes replicase proteins and the spike protein antigen, allowing for reduced doses of 5 ug compared to traditional mRNA vaccines that require 30 ug. However, concerns have been raised, primarily around four misconceptions: shedding, perpetual mRNA replication, integration into human DNA, and its non-approval situation outside Japan. Despite these scientifically unfounded concerns, they have fueled vaccine hesitancy, influenced by misleading information spreading rapidly on social media. Alarmingly, biased statements from an academic university and an academic society aggravate this hesitancy. Japan's history has experienced vaccine hesitancies in human papillomavirus and diphtheria-tetanus-pertussis vaccination cases. To prevent a public health crisis, it is crucial that governmental bodies and academic groups actively counter misinformation, advocating for evidence-based understanding and encouraging vaccination among those most at risk.
期刊介绍:
QJM, a renowned and reputable general medical journal, has been a prominent source of knowledge in the field of internal medicine. With a steadfast commitment to advancing medical science and practice, it features a selection of rigorously reviewed articles.
Released on a monthly basis, QJM encompasses a wide range of article types. These include original papers that contribute innovative research, editorials that offer expert opinions, and reviews that provide comprehensive analyses of specific topics. The journal also presents commentary papers aimed at initiating discussions on controversial subjects and allocates a dedicated section for reader correspondence.
In summary, QJM's reputable standing stems from its enduring presence in the medical community, consistent publication schedule, and diverse range of content designed to inform and engage readers.