研究磁场对尖峰时间编码影响的物理框架

IF 2.3 Q3 ENGINEERING, BIOMEDICAL Biomedical Engineering and Computational Biology Pub Date : 2024-11-04 eCollection Date: 2024-01-01 DOI:10.1177/11795972241272380
Manuel Rivas, Marina Martinez-Garcia
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引用次数: 0

摘要

依赖于尖峰时间模式而非尖峰率的时间神经编码为编码来自弱周期性外部刺激(如静态或极低频电磁场)的信息提供了一种可行的机制。我们的模型侧重于磁场对神经元膜附近神经递质动态的影响。神经递质与膜蛋白上的特定受体位点结合可调节生化反应。神经递质在结合状态下的持续时间是衡量磁场作为化学调节剂能力的指标。通过对配体-受体结合进行物理分析,利用突触传导的α函数,并采用修正版的贝尔定律,我们量化了磁场对结合半衰期时间的影响,以及由此对突触后尖峰计时的影响。
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A Physical Framework to Study the Effect of Magnetic Fields on the Spike-Time Coding.

A temporal neural code reliant on the pattern of spike times rather than spike rates offers a feasible mechanism for encoding information from weak periodic external stimuli, such as static or extremely low-frequency electromagnetic fields. Our model focuses on the influence of magnetic fields on neurotransmitter dynamics near the neuron membrane. Neurotransmitter binding to specific receptor sites on membrane proteins can regulate biochemical reactions. The duration a neurotransmitter spends in the bonded state serves as a metric for the magnetic field's capacity as a chemical regulator. By initiating a physical analysis of ligand-receptor binding, utilizing the alpha function for synaptic conductance, and employing a modified version of Bell's law, we quantified the impact of magnetic fields on the bond half-life time and, consequently, on postsynaptic spike timing.

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