IL-1单核苷酸多态性与幼年特发性关节炎易感性之间的关系:系统综述和荟萃分析。

IF 1 Q3 PEDIATRICS Minerva Pediatrics Pub Date : 2024-11-05 DOI:10.23736/S2724-5276.24.07696-1
Aysan Moeinafshar, Raha Zamani, Nima Rezaei
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引用次数: 0

摘要

导言:幼年特发性关节炎(JIA)是儿童时期最常见的慢性疾病之一,临床表现多种多样。JIA 是由遗传和环境等多因素复杂的相互作用引起的,其中促炎细胞因子基因是研究的重点。本荟萃分析调查了 IL-1A 和 IL-1B 基因多态性与 JIA 易感性之间的关系:共纳入8项研究,涉及1633名患者和2309名对照者,并对IL1A -889 C/T、IL1B -511 C/T和IL1B +3954 C/T与JIA易感性之间的关系进行了荟萃分析:在任何遗传模型或任何种族亚群中,IL1A -889 C/T、IL1B -511 C/T和IL1B +3954 C/T多态性的存在与JIA之间均无明显关联:本研究结果表明,这三种 IL-1 变异不会增加 JIA 的易感性。结论:本研究结果表明,这三种IL-1变异不会增加JIA的易感性。然而,在解释之前必须考虑到研究数量有限和相当程度的异质性。
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Association between IL-1 single nucleotide polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis.

Introduction: Juvenile idiopathic arthritis (JIA) is one of the most common chronic diseases of childhood and presents with various clinical phenotypes. A multifactorial and complex interaction of genetic and environmental factors are responsible for JIA, of which the proinflammatory cytokine genes are of particular research interest. This meta-analysis investigates the association between IL-1A and IL-1B gene polymorphisms and susceptibility to JIA.

Evidence acquisition: A total of eight studies, involving 1633 patients and 2309 controls were included, and a meta-analysis was performed on the association between IL1A -889 C/T, IL1B -511 C/T, and IL1B +3954 C/T, and susceptibility to JIA.

Evidence synthesis: There was no significant association between the presence of IL1A -889 C/T, IL1B -511 C/T, and IL1B +3954 C/T polymorphisms and JIA, under any genetic model or in any ethnicity subgroups.

Conclusions: Results of this study suggest that these three IL-1 variants do not increase the susceptibility to JIA. However, the limited number of studies and the considerable level of heterogeneity must be taken into account before interpretation.

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