化学神经科学经典：抗组胺药物

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-10-15 DOI:10.1021/acschemneuro.4c0050510.1021/acschemneuro.4c00505

Maria O. Nerush, Vadim A. Shevyrin, Nikita I. Golushko, Anastasia M. Moskalenko, Denis B. Rosemberg, Murilo S. De Abreu, Long-En Yang, David S. Galstyan, Lee Wei Lim, Konstantin A. Demin* and Allan V. Kalueff*,

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引用次数: 0

摘要

抗组胺药物在临床上应用广泛，长期以来主要用于治疗由组胺释放引起的严重过敏症。抗组胺药还具有中枢神经系统（CNS）效应，可用作抗焦虑药、催眠药和神经安定药。然而，这类药物也有多种严重的神经药理副作用，如诱发谵妄、亢奋、行为紊乱和幻觉。由于抗组胺药对中枢神经系统有强烈的作用，因此也越来越多地被滥用，偶尔会出现过量和危及生命的毒性反应。在此，我们将讨论抗组胺药物在人类和动物（实验）模型中的化学和神经药理学方面，并概述其作为神经活性物质在当前社会和精神健康方面的重要性。

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Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs

Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances.

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.