{"title":"Glycosmis craibii var. glabra 中的氮氧化物抑制成分","authors":"","doi":"10.1016/S1875-5364(24)60632-1","DOIUrl":null,"url":null,"abstract":"<div><div>Six novel compounds, comprising three quinolones (<strong>1a</strong>, <strong>1b</strong>, and <strong>2</strong>) and three flavanones (<strong>3</strong>–<strong>5</strong>), along with seven known analogs (<strong>6</strong>–<strong>13</strong>), were isolated from the 95% EtOH extract of the stems and leaves of <em>Glycosmis craibii</em> var. <em>glabra</em>. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis. The absolute configurations were determined through Mosher ester and electronic circular dichroism (ECD) spectral analysis. Compounds <strong>2, 6, 9</strong>, and <strong>10</strong> demonstrated inhibition of nitric oxide (NO) production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC<sub>50</sub> values ranging from 13.5 to 20.1 μmol·L<sup>−1</sup>, comparable to the positive control, dexamethasone.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"NO inhibitory constituents from Glycosmis craibii var. glabra\",\"authors\":\"\",\"doi\":\"10.1016/S1875-5364(24)60632-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Six novel compounds, comprising three quinolones (<strong>1a</strong>, <strong>1b</strong>, and <strong>2</strong>) and three flavanones (<strong>3</strong>–<strong>5</strong>), along with seven known analogs (<strong>6</strong>–<strong>13</strong>), were isolated from the 95% EtOH extract of the stems and leaves of <em>Glycosmis craibii</em> var. <em>glabra</em>. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis. The absolute configurations were determined through Mosher ester and electronic circular dichroism (ECD) spectral analysis. Compounds <strong>2, 6, 9</strong>, and <strong>10</strong> demonstrated inhibition of nitric oxide (NO) production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC<sub>50</sub> values ranging from 13.5 to 20.1 μmol·L<sup>−1</sup>, comparable to the positive control, dexamethasone.</div></div>\",\"PeriodicalId\":10002,\"journal\":{\"name\":\"Chinese Journal of Natural Medicines\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Natural Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1875536424606321\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1875536424606321","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
NO inhibitory constituents from Glycosmis craibii var. glabra
Six novel compounds, comprising three quinolones (1a, 1b, and 2) and three flavanones (3–5), along with seven known analogs (6–13), were isolated from the 95% EtOH extract of the stems and leaves of Glycosmis craibii var. glabra. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis. The absolute configurations were determined through Mosher ester and electronic circular dichroism (ECD) spectral analysis. Compounds 2, 6, 9, and 10 demonstrated inhibition of nitric oxide (NO) production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC50 values ranging from 13.5 to 20.1 μmol·L−1, comparable to the positive control, dexamethasone.
期刊介绍：
The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM).
Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
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