A Case of Pseudo-Elevation of CK-MB without Myocardial Infarction.

Background: CK-MB is a subtype of creatine kinase isoenzyme, mainly present in myocardial tissue. When myocardial tissue damage is severe, CK-MB is released into the blood, and the serum level significantly increases, which is an important indicator for diagnosing acute myocardial infarction.

Methods: We reported a case of pseudo-elevation of CK-MB without acute myocardial infarction.

Results: The immunosuppressive assay showed that the activity of CK-MB isoenzyme was 903.0 U/L, which was significantly increased. The patient underwent examinations such as cardiac ultrasound and coronary artery imaging, and no obvious abnormalities were found. Suspected interference, CK-MB was measured using mass immunoassay, and the result was 1.96 ng/mL, which is within the normal range.

Conclusions: When the CK-MB level (immunosuppressive assay) abnormally increases but clinical examination does not support the diagnosis of acute myocardial infarction, laboratory personnel should be aware of the short-comings of this method and use mass immunoassay to detect CK-MB to eliminate interference, and avoid unnecessary examinations and treatments for patients due to inaccurate results.