Causes and Management Strategies for Unusual Hypoglycemia: a Case Series.

Background: Glucose levels are vital for indicating the body's sugar content, with imbalances leading to diseases like diabetes or hypoglycemia-related symptoms such as palpitations and fatigue.

Methods: This case series describes three cases of hypoglycemia identified in recent years, utilizing multiple glucose measurement methods and exploring strategies to eliminate interferences.

Results: Two cases of pseudo-hypoglycemia induced by PEGylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) and Evolocumab injections, and one case of true reactive hypoglycemia following a glucose tolerance test in a patient post-gastric bypass surgery.

Conclusions: For unusual hypoglycemia, collaboration with clinicians and multiple methods is crucial for accurate analysis to differentiate true from pseudo-hypoglycemia, ensuring precise diagnosis and optimal clinical service.