{"title":"揭开脂肪因子的面纱：肌萎缩性脊髓侧索硬化症的荟萃分析和系统综述。","authors":"Hamid Abbasi , Neda Jourabchi-ghadim , Ali Asgarzade , Mobin Mirshekari , Mehrangiz Ebrahimi-Mameghani","doi":"10.1016/j.neuroscience.2024.11.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Adipokines are proposed to be associated with ALS progression through assorted pathways. Therefore, The present <em>meta</em>-analysis explored the link between various adipokines and ALS progression.</div></div><div><h3>Method</h3><div>International database like PubMed, Scopus, and Web of Science databases were searched to achieve eligible papers published before December 2023. The following PICO structure was utilized: Population (patients with ALS); Intervention (serum concentrations of ghrelin, leptin, and adiponectin), Comparison (with or without controls), and Outcome (ALS progression). the risk of bias of selected papers was assessed through the Newcastle-Ottawa Scale (NOS) tool.</div></div><div><h3>Results</h3><div>11 out of 240 papers were selected for this study which were published between 2010 and 2024. Lower serum leptin concentrations were detected in the ALS compared to control groups (WMD: −0.91, 95% CI:-1.77, −0.05). Serum concentrations of adiponectin were higher in ALS compared to control groups (WMD: 0.41, 95% CI:-0.7, 0.89). Ultimately, The serum concentrations of ghrelin in the ALS groups were lower than control groups (WMD: −1.21, 95% CI: −2.95, 0.53).</div></div><div><h3>Conclusion</h3><div>Our findings revealed that serum concentrations of ghrelin and leptin were higher in ALS patients compared to control, unlike adiponectin.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"563 ","pages":"Pages 1-9"},"PeriodicalIF":2.9000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unveiling the veil of adipokines: A meta-analysis and systematic review in amyotrophic lateral sclerosis\",\"authors\":\"Hamid Abbasi , Neda Jourabchi-ghadim , Ali Asgarzade , Mobin Mirshekari , Mehrangiz Ebrahimi-Mameghani\",\"doi\":\"10.1016/j.neuroscience.2024.11.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Adipokines are proposed to be associated with ALS progression through assorted pathways. Therefore, The present <em>meta</em>-analysis explored the link between various adipokines and ALS progression.</div></div><div><h3>Method</h3><div>International database like PubMed, Scopus, and Web of Science databases were searched to achieve eligible papers published before December 2023. The following PICO structure was utilized: Population (patients with ALS); Intervention (serum concentrations of ghrelin, leptin, and adiponectin), Comparison (with or without controls), and Outcome (ALS progression). the risk of bias of selected papers was assessed through the Newcastle-Ottawa Scale (NOS) tool.</div></div><div><h3>Results</h3><div>11 out of 240 papers were selected for this study which were published between 2010 and 2024. Lower serum leptin concentrations were detected in the ALS compared to control groups (WMD: −0.91, 95% CI:-1.77, −0.05). Serum concentrations of adiponectin were higher in ALS compared to control groups (WMD: 0.41, 95% CI:-0.7, 0.89). Ultimately, The serum concentrations of ghrelin in the ALS groups were lower than control groups (WMD: −1.21, 95% CI: −2.95, 0.53).</div></div><div><h3>Conclusion</h3><div>Our findings revealed that serum concentrations of ghrelin and leptin were higher in ALS patients compared to control, unlike adiponectin.</div></div>\",\"PeriodicalId\":19142,\"journal\":{\"name\":\"Neuroscience\",\"volume\":\"563 \",\"pages\":\"Pages 1-9\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306452224005852\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306452224005852","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景：脂肪因子被认为通过各种途径与 ALS 的进展相关。因此，本荟萃分析探讨了各种脂肪因子与 ALS 进展之间的联系：方法：检索 PubMed、Scopus 和 Web of Science 等国际数据库，以获得 2023 年 12 月之前发表的符合条件的论文。采用以下 PICO 结构：通过纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale，NOS）工具对所选论文的偏倚风险进行评估：本研究从 240 篇论文中选取了 11 篇，这些论文发表于 2010 年至 2024 年之间。与对照组相比，ALS患者的血清瘦素浓度较低（WMD：-0.91，95% CI：-1.77，-0.05）。与对照组相比，ALS患者血清中的脂肪连素浓度更高（WMD：0.41，95% CI：-0.7，0.89）。最后，ALS 组血清中胃泌素的浓度低于对照组（WMD：-1.21，95% CI：-2.95，0.53）：我们的研究结果表明，与对照组相比，ALS 患者血清中胃泌素和瘦素的浓度较高，而脂肪连通素则不同。
Unveiling the veil of adipokines: A meta-analysis and systematic review in amyotrophic lateral sclerosis
Background
Adipokines are proposed to be associated with ALS progression through assorted pathways. Therefore, The present meta-analysis explored the link between various adipokines and ALS progression.
Method
International database like PubMed, Scopus, and Web of Science databases were searched to achieve eligible papers published before December 2023. The following PICO structure was utilized: Population (patients with ALS); Intervention (serum concentrations of ghrelin, leptin, and adiponectin), Comparison (with or without controls), and Outcome (ALS progression). the risk of bias of selected papers was assessed through the Newcastle-Ottawa Scale (NOS) tool.
Results
11 out of 240 papers were selected for this study which were published between 2010 and 2024. Lower serum leptin concentrations were detected in the ALS compared to control groups (WMD: −0.91, 95% CI:-1.77, −0.05). Serum concentrations of adiponectin were higher in ALS compared to control groups (WMD: 0.41, 95% CI:-0.7, 0.89). Ultimately, The serum concentrations of ghrelin in the ALS groups were lower than control groups (WMD: −1.21, 95% CI: −2.95, 0.53).
Conclusion
Our findings revealed that serum concentrations of ghrelin and leptin were higher in ALS patients compared to control, unlike adiponectin.
期刊介绍：
Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.
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