环氧米格列奈通过干扰肺癌中的NF-κB和TGF-β/SMAD通路减少辐射诱导的衰老和细胞外基质的形成

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL Phytotherapy Research Pub Date : 2024-11-06 DOI:10.1002/ptr.8352
Heng Zhou, Yong Chen, Ningzu Jiang, Yanxian Ren, Jiayuan Zhuang, Yue Ren, Lin Shen, Chenghao Li
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引用次数: 0

摘要

肺癌是导致癌症相关死亡的主要原因,而放射治疗往往受到肿瘤耐药性和副作用的限制。本研究探讨了发热草中的一种化合物环氧米芝莲内酯(ECL)能否提高肺癌放疗的疗效。我们在 A549 和 PC-9 肺癌细胞系上测试了 ECL,以评估其对 X 射线照射的影响。我们对细胞凋亡、NF-κB通路抑制、TGF-β分泌减少和上皮-间质转化抑制进行了测定。在体内,患有肺肿瘤的C57BL/6小鼠接受了ECL和放射治疗。ECL增强了X射线照射的抗增殖作用,诱导衰老细胞凋亡,抑制NF-κB通路,降低TGF-β水平,抑制上皮-间质转化。ECL 还能抑制肿瘤生长,提高小鼠存活率。ECL 是一种很有前景的肺癌放疗辅助药物,可通过针对多种肿瘤进展机制改善治疗效果。它为加强肺癌的治疗提供了潜力。
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Epoxymicheliolide Reduces Radiation-Induced Senescence and Extracellular Matrix Formation by Disrupting NF-κB and TGF-β/SMAD Pathways in Lung Cancer.

Lung cancer is a major cause of cancer-related mortality, and radiotherapy is often limited by tumor resistance and side effects. This study explores whether epoxymicheliolide (ECL), a compound from feverfew, can enhance radiotherapy efficacy in lung cancer. We tested ECL on A549 and PC-9 lung cancer cell lines to evaluate its effect on x-ray irradiation. We measured apoptosis, NF-κB pathway inhibition, TGF-β secretion reduction, and epithelial-mesenchymal transition suppression. In vivo, C57BL/6 mice with lung tumors received ECL and radiotherapy. ECL enhanced the antiproliferative effects of x-ray irradiation, induced apoptosis in senescent cells, inhibited the NF-κB pathway, reduced TGF-β levels, and suppressed epithelial-mesenchymal transition. ECL also inhibited tumor growth and improved survival in mice. ECL is a promising adjunct to radiotherapy for lung cancer, improving treatment outcomes by targeting multiple tumor progression mechanisms. It offers potential for enhanced management of lung cancer.

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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