增强负载 siRNA 的阴离子脂质体对人类致病真菌烟曲霉的抗真菌活性

IF 5.8 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nanoscale Pub Date : 2024-11-07 DOI:10.1039/d4nr03225j

Yidong Yu, Theresa Vogel, Sina Hirsch, Jürgen Groll, Krystyna Albrecht, Andreas Beilhack

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引用次数: 0

摘要

我们开发了装载 siRNA 的阴离子脂质体，并同时包裹低剂量两性霉素 B，以增强 siRNA 穿透曲霉细胞壁的能力。这些脂质体以三个关键基因的 mRNA 为靶标，明显抑制了真菌的生长，首次证明了 siRNA 对人类真菌病原体的抗真菌潜力。

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Enhanced antifungal activity of siRNA-loaded anionic liposomes against the human pathogenic fungus Aspergillus fumigatus

We developed siRNA-loaded anionic liposomes, co-encapsulating low-dose amphotericin B, to enhance siRNA penetration through the fungal cell wall of Aspergillus fumigatus. Targeting mRNAs of three key genes, these liposomes visibly inhibited fungal growth, demonstrating for the first time the antifungal potential of siRNA against human fungal pathogens.

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来源期刊

Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

12.10

自引率

3.00%

发文量

1628

审稿时长

1.6 months

期刊介绍： Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.