{"title":"脂质纳米颗粒中的多重 RNA：慢性乙型肝炎的潜在治疗疫苗","authors":"Hari Krishnareddy Rachamala, Srujan Marepally","doi":"10.1038/s41392-024-02026-5","DOIUrl":null,"url":null,"abstract":"<p>A recent study published in <i>Signal Transduction and Targeted Therapy</i> by Wenjing Z. and Min Y. et al. presents a potential game-changer in the field of chronic hepatitis B infection. The research focuses on the delivery of multiplexed RNAs using lipid nanoparticles, exploring the synergistic effects of dual small interfering RNAs (siRNAs) targeting the hepatitis B virus (HBV) alongside modulating immune responses with interleukin-2 (IL-2) mRNA.<sup>1</sup></p>","PeriodicalId":21766,"journal":{"name":"Signal Transduction and Targeted Therapy","volume":"5 1","pages":""},"PeriodicalIF":52.7000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B\",\"authors\":\"Hari Krishnareddy Rachamala, Srujan Marepally\",\"doi\":\"10.1038/s41392-024-02026-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A recent study published in <i>Signal Transduction and Targeted Therapy</i> by Wenjing Z. and Min Y. et al. presents a potential game-changer in the field of chronic hepatitis B infection. The research focuses on the delivery of multiplexed RNAs using lipid nanoparticles, exploring the synergistic effects of dual small interfering RNAs (siRNAs) targeting the hepatitis B virus (HBV) alongside modulating immune responses with interleukin-2 (IL-2) mRNA.<sup>1</sup></p>\",\"PeriodicalId\":21766,\"journal\":{\"name\":\"Signal Transduction and Targeted Therapy\",\"volume\":\"5 1\",\"pages\":\"\"},\"PeriodicalIF\":52.7000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Signal Transduction and Targeted Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41392-024-02026-5\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Signal Transduction and Targeted Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41392-024-02026-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
Z. Wenjing 和 Min Y. 等人最近在《信号转导与靶向治疗》（Signal Transduction and Targeted Therapy）杂志上发表的一项研究可能会改变慢性乙型肝炎感染领域的游戏规则。研究重点是利用脂质纳米颗粒递送多重 RNA，探索针对乙型肝炎病毒（HBV）的双重小干扰 RNA（siRNA）与白细胞介素-2（IL-2）mRNA 一起调节免疫反应的协同效应1。
Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B
A recent study published in Signal Transduction and Targeted Therapy by Wenjing Z. and Min Y. et al. presents a potential game-changer in the field of chronic hepatitis B infection. The research focuses on the delivery of multiplexed RNAs using lipid nanoparticles, exploring the synergistic effects of dual small interfering RNAs (siRNAs) targeting the hepatitis B virus (HBV) alongside modulating immune responses with interleukin-2 (IL-2) mRNA.1
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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