要BE还是要PE：主编辑器为基于表位编辑的免疫疗法提供了更多选择

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING Cell stem cell Pub Date : 2024-11-07 DOI:10.1016/j.stem.2024.10.009

S.M. Yin, D.L. Li

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引用次数: 0

摘要

表位编辑是一种保护造血细胞免受免疫疗法根除的有效策略。最近，在《细胞干细胞》（Cell Stem Cell）杂志上，Ji 等人应用碱基编辑（BE）和质粒编辑（PE）改变造血干细胞中 CD123 的表位，用于治疗急性髓性白血病的 CAR-T 疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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To BE or to PE: Prime editors provide more choices for epitope-editing-based immunotherapy

Epitope editing is a promising strategy for protecting hematopoietic cells from eradication by immunotherapies. Recently, in Cell Stem Cell, Ji et al. applied both base editing (BE) and prime editing (PE) to alter the epitope of CD123 in hematopoietic stem cells for CAR-T therapy against acute myeloid leukemia.¹

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.