高效合成 8-氟-10-甲基-3,4-二氢苯并[b][1,6]萘啶-2(1H)-甲酰胺及其细胞毒活性

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC Russian Journal of Organic Chemistry Pub Date : 2024-11-07 DOI:10.1134/S1070428024090203

R. K. Rao, M. Surana, S. Kankala

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引用次数: 0

摘要

研究人员通过偶联反应高产率地合成了一系列新的 8-氟-10-甲基-3,4-二氢苯并[b][1,6]萘啶-2(1H)-甲酰胺杂化物。对合成的化合物进行了体外抗癌活性评估，评估对象包括四种人类肿瘤细胞系，即 MCF-7（乳腺癌）、A-549（肺癌）、OVACR-3（卵巢癌）和 HeLa（宫颈癌）。化合物 12a、12c、12e、12h 和 12l 的活性高于作为阳性对照的顺铂。

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Efficient Synthesis of 8-Fluoro-10-methyl-3,4-dihydrobenzo[b][1,6]naphthyridine-2(1H)-carboxamides and Their Cytotoxic Activity

A facile synthesis of a new series of 8-fluoro-10-methyl-3,4-dihydrobenzo[b][1,6]naphthyridine-2(1H)-carboxamide hybrids in high yields has been developed via coupling reaction. The synthesized compounds were evaluated for their in vitro anticancer activity against a panel of four human tumor cell lines, viz., MCF-7 (breast cancer), A-549 (lung cancer), OVACR-3 (ovarian cancer) and HeLa (cervical cancer). Compounds 12a, 12c, 12e, 12h, and 12l demonstrated higher activity than that of cisplatin taken as positive control.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.