N. A. Ivanova, G. A. Shavaleeva, L. V. Spirikhin, M. S. Miftakhov
{"title":"米索前列醇类似物 11-脱氧-13,14-二脱氢-17-甲基-20-去甲前列腺素 B1 乙酯的合成","authors":"N. A. Ivanova, G. A. Shavaleeva, L. V. Spirikhin, M. S. Miftakhov","doi":"10.1134/S1070428024090094","DOIUrl":null,"url":null,"abstract":"<p>1,2-Addition of lithiated 4-hydroxy-4,5-dimethylhept-1-yne to the keto group of ethyl 7-(5-oxocyclopent-1-en-1-yl)heptanoate, followed by in situ oxidative isomerization of the adduct afforded 11-deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B<sub>1</sub> (PGB<sub>1</sub>) ethyl ester.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of a Misoprostol Analogue, 11-Deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B1 Ethyl Ester\",\"authors\":\"N. A. Ivanova, G. A. Shavaleeva, L. V. Spirikhin, M. S. Miftakhov\",\"doi\":\"10.1134/S1070428024090094\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>1,2-Addition of lithiated 4-hydroxy-4,5-dimethylhept-1-yne to the keto group of ethyl 7-(5-oxocyclopent-1-en-1-yl)heptanoate, followed by in situ oxidative isomerization of the adduct afforded 11-deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B<sub>1</sub> (PGB<sub>1</sub>) ethyl ester.</p>\",\"PeriodicalId\":766,\"journal\":{\"name\":\"Russian Journal of Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070428024090094\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428024090094","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Synthesis of a Misoprostol Analogue, 11-Deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B1 Ethyl Ester
1,2-Addition of lithiated 4-hydroxy-4,5-dimethylhept-1-yne to the keto group of ethyl 7-(5-oxocyclopent-1-en-1-yl)heptanoate, followed by in situ oxidative isomerization of the adduct afforded 11-deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B1 (PGB1) ethyl ester.
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
